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Plasma levels of apolipoprotein E and risk of dementia in the general population


, : Plasma levels of apolipoprotein E and risk of dementia in the general population. Annals of Neurology 77(2): 301-311

The apolipoprotein E (APOE) ε4 allele is a major genetic risk factor for Alzheimer disease and dementia. However, it remains unclear whether plasma levels of apoE confer additional risk. We tested this hypothesis. Using 75,708 participants from the general population, we tested whether low plasma levels of apoE at study enrollment were associated with increased risk of future Alzheimer disease and all dementia, and whether this association was independent of ε2/ε3/ε4 APOE genotype. Multifactorially adjusted hazard ratios (HRs) for Alzheimer disease and all dementia increased from the highest to the lowest apoE tertile (p for trends < 1 × 10(-6) ). Multifactorially adjusted HRs for lowest versus highest tertile were 2.68 (95% confidence interval [CI] = 2.04-3.52) and 1.80 (95% CI = 1.52-2.13) for Alzheimer disease and all dementia, respectively. After further adjustment for ε2/ε3/ε4 APOE genotype, plasma apoE tertiles remained associated with Alzheimer disease (p for trend = 0.007) and all dementia (p for trend = 0.04). Plasma apoE tertiles did not interact with ε2/ε3/ε4 APOE genotype on risk of Alzheimer disease (p = 0.53) or all dementia (p = 0.79). In a subanalysis, the -219G>T GT promoter genotype, associated with low plasma apoE levels, remained significantly associated with increased risk of Alzheimer disease after adjustment for ε2/ε3/ε4 APOE genotype (HR = 1.56, 95% CI = 1.05-2.30). Low plasma levels of apoE are associated with increased risk of future Alzheimer disease and all dementia in the general population, independent of ε2/ε3/ε4 APOE genotype. This is clinically relevant, because no plasma biomarkers are currently implemented. Hence, plasma levels of apoE may be a new, easily accessible preclinical biomarker.

US$19.90

PMID: 25469919

DOI: 10.1002/ana.24326


Other references

Brazitikos, P.D.; Pournaras, C.J.; Tsacopoulos, M.; Munoz, J.L., 1992: Metabolic factors of vasomotor regulation of the inner retina. Lactic acid, the end metabolic product of anaerobic glycolysis is probably the mediator of the hypoxia induced vasodilation on retinal arterioles. In this study we explored the mechanisms of the retinal vasomotor effect of this metabolite by perfo...

Baishukurova A.K., 1980: Changes in erythrocyte 2 3 di phospho glyceric acid concentration in rats under different experimental effects. The 2,3-DPG [diphosphoglyceric acid] concentration in erythrocytes increases in hemic and hypoxic hypoxia. After the effect of hyperoxia and in polycythemia it decreases. The 23-DPG concentration in erythrocytes apparently depends on the organism&...

Kaliuzhin, V.A., 1998: Effect of 2,4-dinitrophenol on stability of a turbidostat yeast culture to heat shock. The resistance of a turbidostat culture of Saccharomyces cerevisiae 14 to heat shock was investigated. The growth rate of the turbidostat culture after a cultivation temperature shift from a suboptimal (20 degrees C) or optimal (30 degrees C) valu...

Anonymous, 1912: Public Health Weekly Reports for JULY 26, 1912. Public Health Reports 27(30): 1173-1230

Slanovec T., 1974: The whey and curds of the alpine region of bohinj. Zbornik Biotehniske Fakultete Univerze v Ljubljani Kmetijstvo 22: 137-150

Harvey H.E.; Chell R.M., 1981: Quantitative determination of morphine sulfate and chloro cresol in morphine sulfate injection by high performance liquid chromatography. A reversed-phase high-performance liquid chromatographic method for morphine sulphate and chlorocresol is described with a mobile phase of aqueous 0.75% ammonium vacetate (pH 7.0)/acetonitrile (70:30 vol/vol), a flow rate of 1.5 ml/min and detecti...

Hemmer, W.; Pauli, U., 1998: Labelling of food products derived from genetically engineered crops. A survey on detection methods. This review provides a survey on approved genetically modified food crops as well as on methods for detecting foods derived from genetically modified organisms. The methods are discussed with special emphasis to their suitability for routine labor...

Goodman, G.T.; Koprowski, H., 1962: Study of the mechanism of innate resistance to virus infection. The resistance of mice to Arbor B viruses was investigated in crossbreeding and backcrossbreeding experiments between the virus-resistant PRI and BRVR mice, and the virus susceptible C3H/He mice. The results of challenging with virus mice from eac...

Chuang, Tsu Yi, 1995: Associated A useful rule to establish causal inference. Journal of Investigative Dermatology 104(4): 620

Ardizzoni, M.; Nipoti, P.; Pillo, L. di; Fantino, M.G., 2002: Fungi involved in oak decline in an urban area. Over the last few decades, oak decline has affected millions of trees in the northern hemisphere. Oak decline was investigated during 1998-2000, in Modena, Emilia Romagna, Italy. Both in vitro and pathogenicity assays were conducted. In in vitro a...