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Predicting symptom severity in autism spectrum disorder based on cortical thickness measures in agglomerative data

, : Predicting symptom severity in autism spectrum disorder based on cortical thickness measures in agglomerative data. Neuroimage (): -

NlmCategory="UNASSIGNED">Machine learning approaches have been widely used for the identification of neuropathology from neuroimaging data. However, these approaches require large samples and suffer from the challenges associated with multi-site, multi-protocol data. We propose a novel approach to address these challenges, and demonstrate its usefulness with the Autism Brain Imaging Data Exchange (ABIDE) database. We predict symptom severity based on cortical thickness measurements from 156 individuals with autism spectrum disorder (ASD) from four different sites. The proposed approach consists of two main stages: a domain adaptation stage using partial least squares regression to maximize the consistency of imaging data across sites; and a learning stage combining support vector regression for regional prediction of severity with elastic-net penalized linear regression for integrating regional predictions into a whole-brain severity prediction. The proposed method performed markedly better than simpler alternatives, better with multi-site than single-site data, and resulted in a considerably higher cross-validated correlation score than has previously been reported in the literature for multi-site data. This demonstration of the utility of the proposed approach for detecting structural brain abnormalities in ASD from the multi-site, multi-protocol ABIDE dataset indicates the potential of designing machine learning methods to meet the challenges of agglomerative data.


PMID: 27664827

DOI: 10.1016/j.neuroimage.2016.09.049

Other references

Novruzova, Z.; Abbasov, R., 1978: Structural characteristics of Artemisia L. species from the Nakhichevan ASSR. Izvestiia Seriia biologicheskikh nauk: ) 12-19

Shrivastava, A.; Singh, K., 2014: The impact of cataract surgery on glaucoma care. To summarize the effects of cataract surgery on the management of glaucoma, in terms of the effect on both the intraocular pressure (IOP) and postoperative diagnostic as well as therapeutic considerations. Recent evidence corroborates prior data d...

Winstanley P.A.; Simooya O.O.; Edwards G.; Orme M.L.; Ekue J.M.K.; Breckenridge A.M., 1989: The disposition of amodiaquine in zambians with malaria. British Journal of Clinical Pharmacology 27(5): 644P

Tierno-De-Figueroa, J.; Sanchez-Ortega, A., 1999: Imaginal feeding of certain systellognathan stonefly species (Insecta: Plecoptera). The digestive contents of adult males and females of 4 species of Systellognathan stoneflies were studied and analyzed: Perla marginata (Perlidae), Isoperla grammatica and I. nevada (Perlodidae) and Chloroperla nevada (Chloroperlidae). The study w...

Lee, P., 2010: Directile dysfunction. Medical Teacher 32(5): 422-424

Montesinos, P.; Rayón, C.; Vellenga, E.; Brunet, S.; González, Jé.; González, M.; Holowiecka, A.; Esteve, J.; Bergua, J.; González, Jé.D.; Rivas, C.; Tormo, M.; Rubio, V.; Bueno, J.; Manso, Félix.; Milone, G.; de la Serna, J.; Pérez, I.; Pérez-Encinas, M.; Krsnik, I.; Ribera, J.M.; Escoda, L.; Lowenberg, B.; Sanz, M.A.; Beltrán de Heredia, J.M.; Hernández, J.M.; Arias, J.; Ramos, F.; Román, A.; de la Serna, J.; Negri, S.; Rayón, C.; Esteve, J.; Fernández-Calvo, F.J.; Díaz-Mediavil, 2011: Clinical significance of CD56 expression in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens. The expression of CD56 antigen in acute promyelocytic leukemia (APL) blasts has been associated with short remission duration and extramedullary relapse. We investigated the clinical significance of CD56 expression in a large series of patients wi...

Kerdelhué, B.; Bojda, F.; Lesieur, P.; Pasqualini, C.; el Abed, A.; Lenoir, V.; Douillet, P.; Chiueh, M.C.; Palkovits, M., 1989: Median eminence dopamine and serotonin neuronal activity. Temporal relationship to preovulatory prolactin and luteinizing hormone surges. Using a high-performance liquid chromatography (HPLC) system coupled with an electrochemical detector, the concentrations of dopamine (DA) and 5-hydroxytryptamine (5-HT) and their major specific metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) a...

Arai, Susumu, 1960: Effects of various hormone preparations on plasma lipids. Absts Papers Jour Japanese Soc Internal Med 49(1/12): 78, / 196

Huf, F.A., 1984: The Shimadzu CS 920 densitometer: illumination of thin layer chromatograms with a parallel light beam and its effects on quantification. The Shimadzu CS 920 has shown to be an easy to handle flying-spot densitometer that enables rapid quantification of thin layer chromatograms. Linear calibration curves with a relative standard deviation of 3 to 4% in the slope can be obtained for...

Butterweck, V.; Khan, S.R., 2009: Herbal medicines in the management of urolithiasis: alternative or complementary?. Kidney stone formation or urolithiasis is a complex process that results from a succession of several physicochemical events including supersaturation, nucleation, growth, aggregation, and retention within the kidneys. Epidemiological data have sh...