geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prediction of taxane and platinum sensitivity in ovarian cancer based on gene expression profiles


, : Prediction of taxane and platinum sensitivity in ovarian cancer based on gene expression profiles. Gynecologic Oncology 141(1): 49-56

Prognoses of ovarian cancer (OC) have improved with the paclitaxel-carboplatin regimen. However, it remains unclear which cases exhibit a genuine benefit from taxane or from platinum. We aimed to predict taxane and platinum sensitivity in OC via gene expression. We identified differentially expressed genes in responsive and resistant cases from advanced OC biopsy expression dataset GSE15622, containing responses to paclitaxel or carboplatin monotherapy. These genes generated a scoring system for prediction of drug response by applying single-sample gene set enrichment analysis. Discriminative metrics termed the T-score and C-score were derived. High C-score levels were significant in responders compared to non-responders in a separate cisplatin treatment dataset (GSE18864, p=0.043). High C-score groups also had significantly better progression-free survival in three OC datasets (The Cancer Genome Atlas, TCGA: p=0.02; GSE9891: p=0.03; GSE30161: p=0.001). In two additional datasets of advanced OC, high T-scores could associate taxane and platinum regimens with better survival than non-taxane and platinum regimens (GSE9891: p<0.0001; GSE3149: p=0.045), whereas in cases with low T-scores, different chemotherapeutic regimens did not result in a significant difference. Assessing TCGA and GSE9891, T-scores were elevated in the C1/Mesenchymal subtype, whereas C-scores were elevated in the C5/Proliferative subtype and were lower in the C1/Mesenchymal subtype (p<0.0001, respectively). C- and T-scores negatively correlated with each other, suggesting complementary roles of taxane and platinum. Our proposal and finding of a scoring system that could predict platinum or taxane response could be useful to develop individualized treatments to ovarian cancer.

US$19.90

PMID: 27016229

DOI: 10.1016/j.ygyno.2016.02.027


Other references

Wojciechowska-Durczyńska, K.; Krawczyk-Rusiecka, K.; Cyniak-Magierska, A.; Zygmunt, A.; Gałecka, E.; Lewiński, A., 2010: Relative quantification of PIK3CA gene expression level in fine-needle aspiration biopsy thyroid specimens collected from patients with papillary thyroid carcinoma and non-toxic goitre by real-time RT-PCR. Recent studies have shown that the phosphatidylinositol 3-kinase (PI3K) signaling pathway is important regulator of many cellular events, including apoptosis, proliferation and motility. PI3K pathway alterations (<i>PIK3CA</i> gene mut...

Lin, L.H.; Wang, L.H., 1995: The effect of chronic pentobarbital treatment on GABA-A receptor delta subunit mRNA level in mouse brain. Society for Neuroscience Abstracts 21(1-3): 1591

Khanna, S.K.; Ross, J.K.; Monro, J.L., 1981: Homograft aortic valve replacement: seven years' experience with antibiotic-treated valves. One hundred and sixty-five patients had their aortic valve replaced with antibiotic-sterilised homograft. In all cases, a two-layered freehand technique of valve implantation was used. Tailoring (narrowing) of the annulus was required in 29 cases,...

Bouillon, R.; Bex, M.; Van Herck, E.; Laureys, J.; Dooms, L.; Lesaffre, E.; Ravussin, E., 1995: Influence of age, sex, and insulin on osteoblast function: osteoblast dysfunction in diabetes mellitus. The osteoblast function was evaluated in normal and diabetic children and adults by measurements of the serum concentration of the carboxy-terminal extension peptide of procollagen (PICP), total and skeletal alkaline phosphatase (ALP), and osteoca...

Turco, G.L.; Ghemi, F.; Segre, G.; Tarquini, A., 1962: Research on the human pulmonary circulation by means of cardiac catheterization and radioactive tracers. Minerva Nucleare 6: 85-90

Teti, A.; Colucci, S.; Grano, M., 1992: Protein kinase C affects microfilaments, bone resorption, and (Ca2+)o sensing in cultured osteoclasts. American Journal of Physiology 263: 30-9

Duconseil, P.; Turrini, O.; Ewald, J.; Berdah, Séphane.V.; Moutardier, V.; Delpero, J-Robert., 2015: Biliary complications after pancreaticoduodenectomy: skinny bile ducts are surgeons' enemies. The aim of this study was to determine the incidence and predisposing factors of biliary complications (BCs) after pancreaticoduodenectomy (PD) and report our experience in managing these BCs. Pancreatic surgery, particularly PD, has benefited fro...

Malliaras, K.; Ibrahim, A.; Tseliou, E.; Liu, W.; Sun, B.; Middleton, R.C.; Seinfeld, J.; Wang, L.; Sharifi, B.G.; Marbán, E., 2015: Stimulation of endogenous cardioblasts by exogenous cell therapy after myocardial infarction. Controversy surrounds the identity, origin, and physiologic role of endogenous cardiomyocyte progenitors in adult mammals. Using an inducible genetic labeling approach to identify small non-myocyte cells expressing cardiac markers, we find that ac...

Cassie J.W.; Cartwright P.B.; Altounyan P., 1999: Coal pillar behaviour from underground stress measurements. Proceedings of the

Murray, M.; Trail, J.C.M.; Grootenhuis, J.G., 1984: Trypanotolerant livestock: potential and future exploitation. This review considers: (i) evidence for the genetic basis of resistance to trypanosomiasis in cattle, sheep, goats and wildlife; (ii) the productivity of trypanotolerant livestock; (iii) environmental factors which influence the stability of trypa...