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Predictive Parameters Identifying Men Eligible for a Sole MRI/Ultrasound Fusion-Guided Targeted Biopsy without an Additional Systematic Biopsy


, : Predictive Parameters Identifying Men Eligible for a Sole MRI/Ultrasound Fusion-Guided Targeted Biopsy without an Additional Systematic Biopsy. Urologia Internationalis (): -

Evaluating the predictive factors that enable identifying men in which a sole MRI/ultrasound (MRI/US) fusion-guided targeted biopsy (TB) detects the maximal prostate cancer (PCa) risk group. Retrospective analysis of 251 consecutive patients who received a sensor-based, real-time MRI/US TB in combination with a 10-core systematic biopsy (SB) between August 2013 and July 2015. Univariate and multivariate binary regression analyses were performed to evaluate the predictors for equal/superior detection of the PCa risk group by TB compared to SB. TB detected PCa in 63% (157/251); SB detected PCa in 70% (176/251); a combination of TB and SB detected PCa in 77% (193/251) of cancer patients. Fifty percent (291/584) of TB cores and 22% (539/2,486) of SB cores showed PCa. Predictors for equal/superior performance of a sole TB were lesion size (maximal diameter; OR 1.050, 95% CI 1.002-1.101, p = 0.043), suspicious digital rectal examination (DRE; OR 2.448, 95% CI 1.062-5.645, p = 0.036) and free/total prostate-specific antigen (PSA) ratio (f/t PSA ratio) ≤0.15 (OR 0.916, 95% CI 0.867-0.967, p = 0.002) on univariate regression analysis and f/t PSA ratio ≤0.15 (OR 0.916, 95% CI 0.867-0.967, p = 0.002) on multivariate regression analysis. The maximal axial diameter of the Prostate Imaging Reporting and Data System-lesion and f/t PSA ratio and a suspicious DRE are possible selection criteria for men eligible for a sole MRI/US fusion-guided targeted prostate biopsy.

US$19.90

PMID: 27618633

DOI: 10.1159/000449258


Other references

N.M.Efremova, 1970: Thyroid function in the early period after resuscitation. Bulletin of Experimental Biology and Medicine 69(2): 115-117

Brooks, P.H.; Beal, J.D.; Niven, S.; Demeckova, V., 2003: Liquid feeding of pigs. II. Potential for improving pig health and food safety. Surveillance studies have shown that liquid feeding reduces Salmonella incidence. This has been particularly associated with the use of acidic residues derived from the food industry. More recently, and particularly because producers wish to feed...

Kamper, J.; Wulff, K., 1993: Early CPAP/minimal handling. Acta Paediatrica 82(10): 900-900

Rebers, S.; van der Valk, T.; Meijer, G.A.; van Leeuwen, F.E.; Schmidt, M.K., 2012: Consent for the secondary use of human residual tissue: the patient is best served by an 'opting-out' procedure. In medical scientific research much use is made of human bodily material (residual tissue) which remains after treatment or diagnosis. Using this, relevant research questions can be answered. The way in which patients can consent to the secondary...

Yip, E.C.H.; Chan, A.S.L.; Pang, H.; Tam, Y.K.; Wong, Y.H., 2006: Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism. Protocatechuic acid (PCA), chlorogenic acid (CA) and luteolin (LT) are plant phenols found in Chinese medicinal herbs such as Lonicera japonica. Cytotoxicity assays showed that PCA, CA and LT (at 100 micro mol/L) effectively killed the HepG2 hepat...

Tomas, V., 1964: On The Prevention Of Epidemics. Ii. Treatment Of Infectious Diseases In The Middle Ages. Casopis Lekaru Ceskych 103: 920-922

Chen, N.; Hollingsworth, M.; Smail, D.; Vladutiu, G.D., 2000: Molecular analysis of human carnitine palmitoyltransferase II deficiencies in the Pichia pastoris expression system. American Journal of Human Genetics 67(4 Supplement 2): 282, October

Traska, M.R., 1986: Killing PIP: another nail in the cash-flow coffin?. Hospitals 60(15): 49-50

Einarsdóttir, J.; Passa, A.; Gunnlaugsson, G., 2001: Health education and cholera in rural Guinea-bissau. The study was undertaken to explore local ideas about cholera and the diffusion of official health educational messages for cholera prevention and to assess whether such messages contributed to changed behavior in the population. During the ongoin...

Badillo, Vm, 1983: Viguiera scandens Badillo, sp. nov. from Venezuela. Ernstia (15) 13-15