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Predictors of survival in parotid adenocarcinoma not otherwise specified: a National Cancer Database study of 3155 patients

, : Predictors of survival in parotid adenocarcinoma not otherwise specified: a National Cancer Database study of 3155 patients. Head & Neck 38(8): 1208-1212

Parotid adenocarcinoma not otherwise specified (PANOS) is a common parotid cancer, but studies specifically on this subject are limited. We conducted a retrospective review of the National Cancer Database. Ten percent of all parotid cancers were PANOS (n = 3155). Median age was 67 years. Most patients were men (62.8%) with high-grade histology (67.2%). Regional metastasis was common (35.9%), whereas occult nodal metastasis (20.2% overall) was less frequent in non-high-grade lesions (8.5% vs 31.6%; p < .001). Distant metastasis was rare (7.9%). Five-year overall survival (OS) was 47%. In multivariate analysis, age, regional metastasis, distant metastasis, high-grade, and T classification were predictors of lower survival. Patients with stage III to IV disease receiving surgery and radiotherapy had a better OS than those receiving surgery alone (51% vs 41%; p < .001). PANOS is an aggressive disease with frequent regional metastasis and low survival. Numerous variables are associated with worse survival. © 2016 Wiley Periodicals, Inc. Head Neck 38:1208-1212, 2016.


PMID: 27166875

DOI: 10.1002/hed.24382

Other references

Noel, James Kingsley, 1964: Tube agglutination and fluorescent antibody techniques for identification of avian pleuro-pneumonia-like organisms. DISSERT ABSTS 24(12 Pt 1): 4922

Douglas, C.P., 1967: To teach this art. Some thoughts on medical education for the 21st centrury. Scottish Medical Journal 12(8): 269-276

Kesler Thomas Lingle, 1960: Lithium raw materials. Pages 521-531 1960

Anonymous, 1993: Prospects and progress in drug design based on peptides and proteins. Keystone symposium. Lake Tahoe, California, March 6-12, 1993. Abstracts. Journal of Cellular Biochemistry. Supplement 17c: 201-237

Brogovan Frincu D L.; Bogdan F., 1971: The dynamics of connective fibrillary elements in the non irradiated and irradiated normal human derma. Morfologia Normala si Patologica (Bucharest) 16(2): 145-153

Wu, Q.; Tang, B.; Huang, N.; Wang, B., 2002: Detection of HNP1 gene expression by RT-PCR in transfected tracheal epithelial cells. By using lipofection reagent DOSPER, the plasmid vector carrying the human neutrophil defensin HNP1 gene(pBabe-Neo-HNP1) was transferred into human, rabbit tracheal epithelial cells cultured in serum-free complement medium. Determination of HNP1 m...

Tanaka, H.; Miyazaki, S.; Sumiyama, Y.; Kakiuchi, T., 2004: Role of macrophages in a mouse model of postoperative MRSA enteritis. Background. We have established a mouse model for fatal postoperative enteritis due to Staphylococcus aureus to analyze mechanisms of bacterial translocation and determine reasons for the lethality of this infection. In the present study the role...

Stultz, C.M.; Edelman, E.R., 2003: A structural model that explains the effects of hyperglycemia on collagenolysis. Prior investigations into the effects hyperglycemia on collagen degradation have yielded conflicting results. We present a new formalism for understanding the biochemistry of collagenolysis and the effects of hyperglycemia on collagen degradation....

Jura Dominik, 2002: Geological controversies of the International Continental Drilling Program (ICDP) in the Gliwice region, in the Moravian-Silesian-Cracovian Variscides, on a slope of Thetis, and in the Carpathian Foredeep and mining basin. Przeglad Geologiczny 50(2): 166-167

Lynn, W., 1984: Radio coverage statistics. The Clearinghouse on Development Communication surveyed 135 countries in Asia, Africa, Europe, North and South America, for U.S.A.I.D., to determine the number of radio and television broadcast stations and receivers. Some of the data were obtaine...