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Prefrontal cortical GABAergic and NMDA glutamatergic regulation of delayed responding


, : Prefrontal cortical GABAergic and NMDA glutamatergic regulation of delayed responding. Neuropharmacology 113(Pt A): 10-20

NlmCategory="UNASSIGNED">NMDA glutamatergic and GABAergic transmission have both been implicated in regulating working memory functions mediated by the prefrontal cortex (PFC), and perturbations in these neurotransmitter systems have been proposed to underlie deficits in these functions observed in schizophrenia. Here, we examined the consequence of disrupting GABAergic or NMDA glutamatergic transmission within the medial PFC of rats on a delayed-response paradigm with translational relevance to working memory tasks used with humans. The operant delayed non-match to position task consisted of a sample phase (one lever extended) and a choice phase wherein rats were required to choose the opposite lever, separated by a variable delay (1-24 s). In well-trained rats, inactivation of the PFC via infusions of GABA agonists baclofen/muscimol (100 ng each) induced delay-independent deficits. Reducing PFC GABA transmission with the GABA-A receptor antagonist bicuculline (12.5-50 ng) also caused delay-independent impairments and increased trial omissions and response latencies during the sample and end-of-delay phases. On the other hand, non-selective blockade of PFC NMDA receptors with MK-801 (3-6 μg) disrupted performance, but these effects more closely resembled delay-dependent impairments. However, selective blockade of GluN2B-containing NMDA receptors with Ro-25-6981 (2.5 μg) did not affect any measures of performance. These results demonstrate that both intact PFC GABA and NMDA receptor signalling are integral for accurate delayed-responding, although they may differentially regulate encoding vs maintenance of information within working memory. Furthermore they suggest that perturbations of both of these neurochemical signals within the PFC may contribute differentially to impairments in working memory observed in schizophrenia.

US$19.90

PMID: 27678413

DOI: 10.1016/j.neuropharm.2016.09.022


Other references

Oberste, M.Steven.; Nix, W.A.; Maher, K.; Pallansch, M.A., 2003: Improved molecular identification of enteroviruses by RT-PCR and amplicon sequencing. Journal of Clinical Virology 26(3): 375-377

Balbuena, J.A.; Raga, J.A., 1993: Intestinal helminth communities of the long-finned pilot whale (Globicephala melas) off the Faroe Islands. The intestines of 170 long-finned pilot whales, Globicephala melas, caught off the Faroe Islands (N.E. Atlantic) were examined for helminth parasites. Eight species were detected but only 4 occurred in at least 10% of the sample. No core or recurr...

Sambuk, S.G., 1987: Oligotrophic Sphagnum Scots pine forests in northwestern European USSR. A comparative phytosociological analysis of Scots pine (Pinus sylvestris) forests of the Sphagnum type in the USSR and elsewhere in northwestern Europe.

Hourihane, J.O'B., 2011: Peanut allergy. Peanut allergy may affect up to 2% of children in some countries, making it one of the most common conditions of childhood. Peanut allergy is a marker of a broad and possibly severe atopic phenotype. Nearly all children with peanut allergy have ot...

Vazzaz M.C.; Curri G.; Mian G.; Negro C.; L'abbate M., 1985: Statistical study on in hospital and extra hospital care of a sample of geriatrics ward patients. Giornale di Gerontologia 33(8): 639-646

Nishihori, T.; Abdo-Matkiwsky, M.; Fleishman, S.B.; Blum, R.H., 2005: Severe action tremor related to interferon-alpha 2b therapy for malignant melanoma. Interferon (IFN)-alpha 2b is used for adjuvant therapy in malignant melanoma. Neurotoxicity as a side effect has been well described. Resting and action tremor related to interferon have been reported but are relatively uncommon. We report a case...

Thomas, D.C.; Whittemore, A.S., 1988: Methods for testing interactions, with applications to occupational exposures, smoking, and lung cancer. Various approaches to assessing the interaction between smoking and occupational exposures are described. The definition of interaction depends on the measure of association under consideration and can be expressed in terms of disease risk, time,...

Lai, M.C.; Ciulla, R.; Roberts, M.F.; Sowers, K.R.; Gunsalus, R.P., 1995: Extraction and detection of compatible intracellular solutes. Sowers, K R [Editor], Schreier, H J [Editor] Archaea: Methanogens: A laboratory manual 349-368

Goldman, B., 1988: Mastering environmental emergencies with your computer. Cmaj 138(1): 67-68

Kimura, Y.; Okuda, H.; Tani, T.; Arichi, S., 1982: Studies on scutellariae radix of scutellaria baicalensis 6. effects of flavanone compounds on lipid per oxidation in rat liver. Compounds which inhibited lipid peroxides formation (in in vitro experiments) were isolated together with various flavonoids from the roots of S. baicalensis. From the analytical and physical data, the compounds were identified as (2S)-2',5,6...