geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort


, : Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort. Bmj Open 5(10): E008213-E008213

To evaluate in an Italian cohort the incidence of venous thromboembolic events (VTE) in pregnancies after assisted reproductive technologies (ART). Thrombosis and Haemostasis Unit at I.R.C.C.S. 'Casa Sollievo della Sofferenza', S. Giovanni Rotondo. A prospective cohort of 998 women advised to undergo ART was referred by local fertility clinics from April 2002 to July 2011. Follow-up information was obtained during the check-up and/or by phone interviews. In a cohort of women who consecutively gave birth (n=3339) after spontaneous conception in our Institution, information on the diagnoses of pregnancy-related venous thromboses was obtained by linkage to a patient administrative register. We calculated the incidence of VTE and superficial venous thrombosis in successful ART cycles and compared it with that of the general population conceiving spontaneously. Overall, 684 ART cycles were carried out by 234 women, who achieved a clinical pregnancy; in case of more than one successful cycle, only the first pregnancy was considered. Three vein thromboses (two VTE and one superficial vein thrombosis) were recorded. An antithrombotic prophylaxis with LMWH alone or combined with low-dose aspirin was prescribed in 23/234 (9.8%) women. In the reference cohort of 3339 women, a total of 11 vein thromboses were observed: six VTE and five SVT. The two-tailed Fisher exact test showed a trend towards statistical significance (p: 0.06, OR: 3.9, 95% CI 0.87 to 15.3). After the exclusion of superficial thromboses in both the groups, we found that the incidence of VTE in our population of women who had undergone ART was 2/234 pregnancies (8.5 ‰), whereas that in our reference population was 6/3339 (1.8 ‰) (p: 0.09). Our data show a slightly higher incidence of vein thromboses in pregnancies after ART than in those after natural conception.

US$19.90

PMID: 26443651

DOI: 10.1136/bmjopen-2015-008213


Other references

Barbachyn, M., R.; Hutchinson, D., K.; Toops, D., S.; Reid, R., J.; Zurenko, G., E.; Yagi, B., H.; Schaadt, R., D.; Allison, J., W., 1993: U-87947E, a potent quinolone antibacterial agent incorporating a bicyclo(1.1.1)pent-1-yl (BCP) subunit. Incorporation of a bicyclo(1.1.1)pent-1-yl group at the N-1 position of quinolone antibacterial agents affords compounds with potent activity. One of these analogs, U-87947E, exhibits enhanced activity relative to that of ciprofloxacin against gra...

Dunn, F.B., 2001: Anthrax as a cancer drug?. Journal of the National Cancer Institute 93(22): 1680-1681

Nordam, A.; Torjuul, K.; Sørlie, V., 2005: Ethical challenges in the care of older people and risk of being burned out among male nurses. The aim of this study was to illuminate the meaning of being in ethically difficult situations when caring for older people, as experienced by male nurses. Nurses and physicians are frequently faced with ethical issues and challenges in their work...

Fuster, S.; Costaguta, A.; Tabacco, O., 1998: Sclerotherapy of bleeding gastric varices with cyanoacrylate in children. Gastroenterology 114(4 PART 2): A1244, April 15

Selitskaia, T.I., 1966: Histochemical investigations of the eyes in experimental ateriosclerosis. Oftalmologicheskii Zhurnal 21(5): 386-386

Smith, R.J.; Epps, D.E.; Justen, J.M.; Sam, L.M.; Wynalda, M.A.; Fitzpatrick, F.A.; Yein, F.S., 1987: Human neutrophil activation with interleukin-1. A role for intracellular calcium and arachidonic acid lipoxygenation. Human monocyte-derived interleukin-1 (IL-1) stimulated the selective extracellular release of cytoplasmic granule-associated elastase from human neutrophils. Although extracellular calcium (Ca2+) enhances but is not required for the expression of...

Dinov, P., 1970: Pre-sowing cultivation of the so. Agrotekhnika na polsite kulturi: 9-58

Lho, D.S.; Hong, J.K.; Paek, H.K.; Lee, J.A.; Park, J., 1990: Determination of phenolalkylamines, narcotic analgesics, and beta-blockers by gas chromatography/mass spectrometry. An analytical procedure for determination of phenolalkylamines, narcotic analgesics, and beta-blockers in urine by gas chromatography/mass spectrometry (GC/MS) is described. The detection of phenolalkylamines, narcotic analgesics, and beta-blocker...

Xie, S-tao.; Chen, B.; Tao, K., 2007: Purification, identification and oriented differentiation of endothelial progenitor cells from human umbilical cord blood. To explore the endothelial progenitor cell markers and biological characteristics of human CD133 umbilical cord blood cells( EPC). CD133+ cells were enriched from human umbilical cord blood by immunomagnetic sorting, and cultured with EGM-2MV medi...

Van Vrancken, C.; Bopp, C.M.; Reis, J.P.; DuBose, K.D.; Kirtland, K.A.; Ainsworth, B.E., 2004: The prevalence of leisure-time physical activity among diabetics in South Carolina. Background: Diabetes is the seventh leading cause of death among South Carolinians. The benefit of physical activity on the control and prevention of diabetes has been established. This study determined the prevalence of leisure-time physical acti...