+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Preserved anterograde and remote memory in drug-responsive temporal lobe epileptic patients

, : Preserved anterograde and remote memory in drug-responsive temporal lobe epileptic patients. Epilepsy Research 115(): 126-132

To investigate cognition, particularly anterograde and remote memory, in patients suffering from unilateral drug-responsive mesial temporal lobe epilepsy (mTLE) patients and to compare their performance with that observed in drug-resistant mTLE patients. Sixteen drug-responsive mTLE patients, with only infrequent seizures in their lifetime, were matched for demographic and clinical variables to 18 patients suffering from drug-resistant unilateral mTLE. A comprehensive neuropsychological examination, including baseline, anterograde memory tasks, and a large range of remote memory tests was carried out. Patients with drug-responsive epilepsy obtained average scores on every anterograde memory test. Although in general, they obtained lower scores than the healthy controls on remote memory tests, the differences failed to reach significance. Moreover, the drug-responsive group performed significantly better than the drug-resistant group on anterograde recall tests and an episodic autobiographical memory test. Performance was not significantly different between the patient groups in personal semantics or memory for public events. Our results show that a mild clinical course of mTLE with no cognitive deficits can occur notwithstanding hippocampal sclerosis. The differences in cognitive function between the two groups are likely due to distinct pathophysiology of the underlying cause of epilepsy. Drug-resistant seizures and cognitive deficits may be the consequence of a more severe underlying cerebral process. Better understanding of the variety of pathogenesis of mTLE could help to answer this open question.


PMID: 26220389

DOI: 10.1016/j.eplepsyres.2015.06.006

Other references

Garrette, Rj, 1974: Reproduction in mink on the physiological basis. II. Mating, ovulation, and fertilization. American mink breeder magazine: 2 (3) 12-13

Anonymous, 2013: Structure of Intratumor Heterogeneity Is Cancer Hedging Its Bets?. Development of resistance limits transferability of most anticancer therapiesinto curative treatment and understanding mechanisms beyond it remains a bigchallenge. Many high resolution experimental observations show enormousintratumor heterogeneit...

Morawietz, H.; Rueckschloss, U.; Niemann, B.; Duerrschmidt, N.; Galle, J.; Hakim, K.; Zerkowski, H.R.; Sawamura, T.; Holtz, J., 1999: Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein. Background-Oxidatively modified LDL (oxLDL) plays an important role in the development of atherosclerosis. OxLDL effects, eg, foam cell formation, are mediated in part by the classic scavenger receptor, whereas other effects may involve the recent...

Sera, N.; Morita, K.; Nagasoe, M.; Tokieda, H.; Kitaura, T.; Tokiwa, H., 2005: Binding effect of polychlorinated compounds and environmental carcinogens on rice bran fiber. To accelerate the fecal excretion of polycyclic biphenyl (PCB), polychlorinated dibenzofurans (PCDFs), polychlorinated-p-dioxines (PCDDs) and various mutagens and carcinogens, their binding effect on rice bran fiber (RBF) was investigated for nine...

Wilson, F.E.; Brandon, D.M.; Leonards, W.J., 1979: Rice fertilization. Determination of requirements of new rice varieties. The opt. N fertilizer levels for rice cv. Saturn, Mars, Melrose, Lebonnet, Newrex, RU-026, RU-078, Starbonnet and Bellevue were determined in field trials on silt loam soil. Yields of Saturn were opt. at 100 lb N/ac whereas Mars and Melrose yields...

Ibatullin M.M., 1986: Clinical evaluation of perifocal edema in patients with brain tumors of supratentorial localization. Kazanskii Meditsinskii Zhurnal: 193

Dovring, F., 1984: Energy use for Midwest agriculture. In this study the direct and indirect use of energy in and for Midwest agriculture in 1978 was determined by examining data from the Firm Enterprise Data System and from resources developed by the University of Illinois Energy Research Group. Over...

Jeffreys D.A., 1970: Striate and extra striate origins of pattern related visual evoked potential components. Journal Of Physiology (cambridge): 29p-30p

Zhang, J.; Gao, W.; Li, X.; Wang, J.; Li, L., 2011: Induction of Periploca sepium in vitro plantlet and studies on dynamic accumulation of periplocin. To analyze the content of periplocin in different part of the Periploca sepium in vitro plantlet and study its dynamic variation during the process of differentiation. The seeds were generated seedling under aseptic condition, and the cut hypocoty...

Snow, T., 2013: Global study shows UK lags behind in newly qualified nurse numbers. Nursing Standard 1987) 27(13): 9-9