geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prevalence and predictors of anxiety and depression after completion of chemotherapy for childhood acute lymphoblastic leukemia: A prospective longitudinal study


, : Prevalence and predictors of anxiety and depression after completion of chemotherapy for childhood acute lymphoblastic leukemia: A prospective longitudinal study. Cancer 122(10): 1608-1617

The months immediately after the completion of treatment for childhood acute lymphoblastic leukemia (ALL) are often regarded as a stressful time for children and families. In this prospective, longitudinal study, the prevalence and predictors of anxiety and depressive symptoms after the completion of treatment were examined. Participants included 160 children aged 2 to 9 years with standard-risk ALL who were enrolled on Children's Oncology Group protocol AALL0331. Parents completed standardized rating scales of their children's emotional-behavioral functioning and measures of coping and family functioning at approximately 1 month, 6 months, and 12 months after diagnosis and again 3 months after the completion of chemotherapy. At 3 months off therapy, approximately 24% of survivors had at-risk/clinically elevated anxiety scores and 28% had elevated depression scores, which are significantly higher than the expected 15% in the general population (P = .028 and .001, respectively). Patients with elevated anxiety 1 month after diagnosis were at greater risk of off-therapy anxiety (odds ratio, 4.1; 95% confidence interval, 1.31-12.73 [P = .022]) and those with elevated depressive symptoms 6 months after diagnosis were at greater risk of off-therapy depression (odds ratio, 7.88; 95% confidence interval, 2.61-23.81 [P = .0002]). In adjusted longitudinal analyses, unhealthy family functioning (P = .008) and less reliance on social support coping (P = .009) were found to be associated with risk of emotional distress. Children from Spanish-speaking families (P = .05) also were found to be at a greater risk of distress. A significant percentage of children experience emotional distress during and after therapy for ALL. These data provide a compelling rationale for targeted early screening and psychosocial interventions to support family functioning and coping skills. Cancer 2016;122:1608-17. © 2015 American Cancer Society.

US$19.90

PMID: 27028090

DOI: 10.1002/cncr.29946


Other references

Kolganova D.N.; Sukhova T.F.; Sazonova V.M., 1989: A method for obtaining sodium allylsulfonate. Khimiko-Farmatsevticheskii Zhurnal 23(9): 1129

Inverso, M.; Lukas, G.N.; Weidenbach, S.J., 1980: Caprine bluetongue virus isolations. Viral isolation procedures demonstrated the presence of bluetongue virus serotypes 10, 11 and 17 in 26 tissue specimens submitted for routine testing. The goats in this report showed one or more of the following signs or lesions: weakness, pulmona...

Thompson, R.G.; White, C.B.; Hailey, H., 1948: Granuloma inguinale; report of three cases treated with massive doses of streptomycin. Southern Medical Journal 41(11): 994-997

Comyns, T.M.; Harrison, A.J.; Hennessy, L.K., 2010: Effect of squatting on sprinting performance and repeated exposure to complex training in male rugby players. This study was undertaken to examine the effect of a heavy weight training exercise on sprinting performance and on the effect of repeated exposure to a complex training protocol. Eleven male rugby union players (age 20.9 +/- 3.1 years) participat...

Liccardi, G.; Infantino, A.; Paggiaro, P.; Fabbri, L.Maria.; Salzillo, A.; Infantino, R.; D'Amato, G., 2012: GPs' role in reducing the risk of bronchospasm in asthma patients undergoing general anesthesia and/or intravascular administration of radiographic contrast media. Primary Care Respiratory Journal 20(3): 333-335

Lidror, A.; Prigojin, I.; Pasternak, H., 1992: Quality inspection of fruit and vegetables with computer support. An effective, computerized quality inspection system was developed in which the decisions and regulatory rules were assigned to the computer. An algorithm for a highly complicated statistical sequential sampling procedure was developed, using port...

Sawicki, W.; Rowinski, J.; Maciejewski, W.; Kwarecki, K., 1968: Kinetics of proliferation and migration of epithelial cells in the guinea pig colon. Experimental Cell Research 50(1): 93-103

Rhoades D.A.; Dowrick D.J., 2000: Effects of magnitude uncertainties on seismic hazard estimates. The purpose of this paper is to demonstrate by way of theory and examples the effects that magnitude uncertainties can have on different components of a seismic hazard model, and to describe methods for handling such uncertainties. Uncertainties i...

Kono, M.; Crouch, R.K.; Oprian, D.D., 2001: Spectral tuning of the salamander UV cone pigment. IOVS 42(4): S184, March 15

Hillman, R., 1977: Polygenic control of Drosophila morphogenesis during the stages of determination and specification of adult structures. American zoologist: er 17 (3) 521-533