+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum

, : Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum. Iranian Journal of Basic Medical Sciences 17(11): 879-885

To clarify the protective effects of Cichorium glandulosum (CG) extracts on thioacetamide (TAA)-induced rat hepatic fibrosis. The dry roots of CG were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (CG-V), ethyl acetate extract (CG-VI) and n-butyl alcohol extract (CG-VII). Thirty-six Wistar rats were randomly divided into a normal group, a model group, a CG-V group (15 mg/kg), a CG-VI group (3 mg/kg), a CG-VII group (6 mg/kg) and a positive drug group (silibinin capsule, 8 mg/kg). Organ indices and serum levels of glutamic-oxaloacetic and glutamic-pyruvic transaminases of intragastrically administered rats were obtained. Expressions of FN, Smad3, IGFBPrP1 and TGF-β1 genes were detected by Western Blot and immunohistochemical assays. Apoptosis was examined by TUNEL assay. Hepatic fibrosis of treatment groups was evidently mitigated. Expressions of FN, Smad3 and TGF-β1 in administration groups were higher than those in normal group, and moreover were significantly higher in CG-V and CG-VII groups than those of model group. Apoptotic index of model group was significantly higher than that of normal group, but indices of CG-V and CG-VII groups were significantly lower than that of model group. Significantly more FN, Smad3 and IGFBPrP1 were expressed in treatment groups than those in normal group. CG extracts may function by altering TGF-β/Smads signal transduction pathway.


PMID: 25691930

Other references

Blaski, M., 2004: Seasonal dynamics of Ceratophyllus hirundinis (Curtis, 1826) (Siphonaptera, Insecta) in the nests of Delichon urbica (L.). The annual cycle of Ceratophyllus hirundinis was studied in 61 nests of Delichon urbica [Poland]. Fleas were observed in 45 nests. The abundance of adult fleas peaked in March and October; abundance was higher in October than in March. There were...

Halliday A.N.; Holden P.; Davidson J.P.; Lee D.C.; Dickin A.P.; Dempster T.J.; Hamilton P.J.; Hunter R.H.; Upton B.G.J., 1988: Disturbed Nd, Sr and Pb isotopic systems in granulite facies and ultramafic xenoliths and the misrepresentation of crust and mantle isotopic reservoirs. Eos, Transactions, American Geophysical Union 69(44): 1516

Fernandes, C.J.; Rong, L.; Tamura, T.; Stewart, K.D.; Rogers, L.K.; Mcmicken, H.W.; Elliston, J.F.; Hansen, T.N.; Smith, C.V., 2002: Stable transfection of Chinese hamster ovary cells with glutamate-cysteine ligase catalytic subunit cDNA confers increased resistance to tert-butyl hydroperoxide toxicity. Glutathione (GSH) plays vital roles in antioxidant defense mechanisms. To determine whether gene transfection strategies could be used to enhance GSH synthetic capacities and protect mammalian cells against oxidant stresses, we used liposome-media...

Friederich H.C.; Gloor M., 1971: Experimental investigations on size modifications of full thickness auto grafts in man. Archiv fuer Dermatologische Forschung 241(1): 56-64

Nanjan, K.; Muthuswamy, S., 1974: Foliar feeding of Edward rose (Rosa bourboniana Desp.). A comparison of 4 NPK treatments with water spray and control showed that all the foliar nutrient treatments increased the flowering shoot length, number of shoots/plant and flower yield of Edward roses. The treatment supplying 1.27 g N, 0.88 g P2...

Hammerman, I.S.; Avtalion, R.R., 1979: Sex determination in Sarotherodon (tilapia) : Part 2: the sex ratio as a tool for the determination of genotype - a model of autosomal and gonosomal influence. The simplest possible model of the sex determination process adding autosomal influence to a minimal number of sex chromosomes was developed to explain matings of Tilapia (Sarotherodon) species. Eighteen different genotypes, each having two autoso...

Babiak G., 1972: Contribution to the knowledge of butterfly fauna of the mansfeld lake district. Entomologische Nachrichten 16(6): 57-66

Abe, T.; Tsuiki, T.; Murai, K.; Sasamori, S., 1990: Statistical study of 41 cases with denture foreign bodies in the air and food passages and significance of the duplicated denture model. A statistical study of 41 cases with denture foreign bodies in the air and upper food passages which were treated in our department during the past 21 years was done. (1) Males were more frequently affected. The ratio of male to female was about 2...

Lennon, Robert E., 1961: The trout fishery in Shenandoah National Park. Populations of brook trout in streams of Shenandoah National Park were reduced drastically early in the past decade by a succession of unuaually severe droughts and floods. The drying of stream beds, predation, and scouring were principal factors...

Papaconstantinou, C.; Caragitsou, E., 1986: Impact of slag deposition on demersal fish assemblages in the n. Euvoikos Gulf. Rapports et Proces-Verbaux des Reunions Commission Internationale pour l'Exploration Scientifique de la Mer Mediterranee Monaco, 302: 129