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Proton channels and renal hypertensive injury: a key piece of the Dahl salt-sensitive rat puzzle?

, : Proton channels and renal hypertensive injury: a key piece of the Dahl salt-sensitive rat puzzle?. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 310(8): R679-R690

Hv1 is a voltage-gated proton channel highly expressed in phagocytic cells, where it participates in the NADPH oxidase-dependent respiratory burst. We have recently identified Hv1 as a novel renal channel, expressed in the renal medullary thick ascending limb that appears to importantly contribute to the pathogenesis of renal hypertensive injury in the Dahl salt-sensitive rat model. The purpose of this review is to describe the experimental approaches that we have undertaken to identify the source of excess reactive oxygen species production in the renal outer medulla of Dahl salt-sensitive rats and the resulting evidence that the voltage-gated proton channel Hv1 mediates augmented superoxide production and contributes to renal medullary oxidative stress and renal injury. In addition, we will attempt to point out areas of current controversy, as well as propose areas in which further experimental studies are likely to move the field forward. The content of the following review was presented as part of the Water and Electrolyte Homeostasis Section New Investigator Award talk at Experimental Biology 2014.


PMID: 26843580

DOI: 10.1152/ajpregu.00115.2015

Other references

Ben-Yehoshua, S., 1976: Care of various vegetables af. Hassadeh 56 (4) 575-576

Speer J.Alexander, 1981: The nature and magnetic expression of isograds in the contact aureole of the Liberty Hill Pluton, South Carolina. Geological Society of America Bulletin 92(9): I 603-I 609, II 1262-II 1358

Rechcigl J.E.; Payne G.G.; Bottcher A.B.; Porter P.S., 1992: Reduced phosphorus application on bahiagrass and water quality. Phosphorus is considered to be the major factor causing eutrophication of Lake Okeechobee and other waterways in Florida [USA]. An important source of P for Lake Okeechobee is runoff of soluble P fertilizer applied to bahiagrass (Paspalum notatum...

Dowd, B.; Walker-Smith, J.; Gee, S.; Aretaeus, 1974: Samuel Gee, Aretaeus, and the coeliac affection. British Medical Journal 2(5909): 45-47

Chaves, A.; Mugridge, A.; Fernandez Lozano, J.; Limongelli, J.C., 1998: Biodegradable and biodesintegrable films employed for the storage of long-life tomatoes. Tomato cv. R-190 (Graziella) fruits were harvested at USDA ripening stage 6, were packed in fours in one of the following films: Ecostar 5, 10 and 15 p. 100 (biodisintegrable) or Mater-bi (biodegradable). For comparison, non-degradable PVC and RD-...

Garmendia, F.; Pfeiffer, E.F.; Vaubel, W.E.; Retiene, K., 1965: Evaluation of the methods of determination of ACTH activities in human blood. Revista de la Sociedad Peruana de Endocrinologia 2(1): 8-29

Lee Y.W., 1986: Trichothecene production by myrothecium roridum on various media. Abstracts Of The Annual Meeting Of The American Society For Microbiology: 1

Stoewsand, G.S.; Robinson, W.B., 1972: Malnutrition: cause of toxic reponse of chicks fed varietal grape juices. Twelve replicated experimental treatments were continued for 42 days on groups of locally purchased day-old chicks, 8 to 10 in a group, males and females equally divided. Four diets and three drinking liquids were used. The diets were a German mix...

Ota, A.; Nakao, H.; Sawada, Y.; Karnan, S.; Wahiduzzaman, M.; Inoue, T.; Kobayashi, Y.; Yamamoto, T.; Ishii, N.; Ohashi, T.; Nakade, Y.; Sato, K.; Itoh, K.; Konishi, H.; Hosokawa, Y.; Yoneda, M., 2016: Δ40p53α suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells. Splice variants of certain genes impact on genetic biodiversity in mammals. The tumor suppressor TP53 gene (encoding p53) plays an important role in the regulation of tumorigenesis in hepatocellular carcinoma (HCC). Δ40p53α is a naturally occurr...

Manum, Svein, 1966: Ginkgo spitsbergensis n. sp. from the Paleocene of Spitsbergen and a discussion of certain Tertiary species of Ginkgo from Europe and North America. Ginkgo spitsbergensis n. sp. is described on new material from the Paleocene of Spitsbergen, with particular regard to its epidermal characters. Probably all the older finds of Ginkgo in the Spitsbergen Tertiary should be referred to the new speci...