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Protozoal infections of the cornea and conjunctiva in dogs associated with chronic ocular surface disease and topical immunosuppression


, : Protozoal infections of the cornea and conjunctiva in dogs associated with chronic ocular surface disease and topical immunosuppression. Veterinary Ophthalmology 19(3): 206-213

To describe five cases of protozoal keratitis or conjunctivitis in dogs with chronic preexisting ocular surface disease treated with long-term immunosuppression. Five dogs that developed corneal or conjunctival mass lesions. The database of the Comparative Ocular Pathology Laboratory of Wisconsin was searched for canine cases diagnosed with corneal or conjunctival protozoal infection. Five cases were identified, and tissues were examined using routine and special histochemical stains: immunohistochemical labels for Neospora caninum, Toxoplasma gondii, and Leishmania spp., and tissue sample PCR for Leishmania spp., Trypanosoma cruzi, tissue coccidia (i.e., T. gondii/Sarcocystis/Neospora), piroplasms, trichomonads, and Acanthamoeba. Electron microscopy was performed for two cases, and serology for N. caninum and T. gondii was available for three cases. Preexisting ocular diseases included keratoconjunctivitis sicca and pigmentary keratitis (n = 4) and pyogranulomatous meibomian adenitis (n = 1). All dogs were treated with tacrolimus or cyclosporine for at least 1.2 years. Dogs were presented with fleshy corneal or conjunctival masses that were clinically suspected to be neoplastic (n = 4) or immune mediated (n = 1). Histologic examination revealed granulomatous inflammation with intralesional protozoal organisms. Amoeba (n = 2), T. gondii (n = 2), or Leishmania mexicana (n = 1) were identified using molecular techniques. Serological tests were negative. Protozoal keratitis and conjunctivitis without systemic involvement appears rare and may be associated with chronic preexisting ocular surface disease treated with long-term immunosuppression. Based upon clinical appearance, lesions could be confused with neoplasia. This is the first report of amoebic keratoconjunctivitis in dogs and of L. mexicana in dogs in the United States.

US$19.90

PMID: 26037023

DOI: 10.1111/vop.12285


Other references

Khoshnood, B.; Pryde, P.; Wall, S.; Singh, J.; Mittendorf, R.; Lee, K.S., 2000: Ethnic differences in the impact of advanced maternal age on birth prevalence of Down syndrome. Objectives: This study explored whether ethnic differences in the impact of advanced maternal age on the risk of Down syndrome might reflect differences in use of prenatal diagnostic technologies. Methods: Maternal age-specific odds of Down syndro...

Martinovich, V.S.ucsne-Kecskemeti, K., 1983: Population dynamics studies of garden pea aphids (Acyrtosiphon pisum Harris) in pea seed production. Zoldsegtermesztesi Kutato Intezet bulletinje = Bulletin of the Vegetable Crops Research Institute6(16): 115-130

Kim, J.; Saidel, G.M.; Kalhan, S.C., 2011: Regulation of Adipose Tissue Metabolism in Humans: Analysis of Responses to the Hyperinsulinemic-Euglycemic Clamp Experiment. The suppression of lipolysis is one of the key metabolic responses of the adipose tissue during hyperinsulinemia. The failure to respond and resulting increase in plasma fatty acids could contribute to the development of insulin resistance and per...

Aghib, D.; Ottolenghi, S.; Rocchi, M.; Guerrasio, A.; Saglio, G., 1987: A novel type of c-myc translocation in a T lymphoma cell line. Annals of the New York Academy of Sciences 511: 338-342

Zunino, P.; Campisi, C., 1978: Problems of per os realimentation after total parenteral nutrition in patients subjected to radical surgery of the pancreas. Minerva Dietologica E Gastroenterologica 24(4): 293-298

Rogers, W.A., 1978: The principal parasitic diseases of warm-water fishes. The major diseases in warm water fish caused by protozoa, helminths and crustacea are briefly discussed.

Vierke, J., 1987: Schaumnestbauer, die kein Schaumnest brauchen. Eiklumpenbildung - eine bisher nicht beachtete Fortpflanzungsstrategie bei Labyrinthfischen. Aquarien Magazin, 213: 99-104

Eggington, A.R., 1986: Chemical composition of monsoon tallgrass pastures on the Marrakai land system of the Northern Territory. Chemical composition of whole leaves of Sorghum plumosum, Themeda triandra and Chrysopogon latifolius were assessed monthly from Oct. 1979 to Sept. 1981. N, P and DDM of these 3 species and Chrysopogon fallax, Heteropogon triticeus, H. contortus,...

Noronha, V.; Shafi, N.Q.; Obando, J.Antonio.; Kummar, S., 2005: Primary non-Hodgkin's lymphoma of the liver. We review the literature on primary hepatic lymphoma (PHL). PHL is a rare malignancy, and constitutes about 0.016% of all cases of non-Hodgkin's lymphoma. It has been reported to occur with increased frequency in patients with chronic hepatit...

Kalfine E., 1973: Ultrastructure of mycobacterium phlei under the influence of ethambutol. Archives De L'Union Medicale Balkanique: 471-474