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Pulmonary neuroendocrine cells function as airway sensors to control lung immune response

, : Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science 351(6274): 707-710

The lung is constantly exposed to environmental atmospheric cues. How it senses and responds to these cues is poorly defined. Here, we show that Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population. Robo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers increased neuropeptide production upon exposure to air. Excess neuropeptides lead to an increase in immune infiltrates, which in turn remodel the matrix and irreversibly simplify the alveoli. We demonstrate in vivo that PNECs act as precise airway sensors that elicit immune responses via neuropeptides. These findings suggest that the PNEC and neuropeptide abnormalities documented in a wide array of pulmonary diseases may profoundly affect symptoms and progression.


PMID: 26743624

DOI: 10.1126/science.aad7969

Other references

Nolans, A., 2008: Dose of realism. Health Service Journal: 22-27

Linklater, K.A.; Imlah, P., 1974: Serological techniques for the detection of antibodies to porcine thrombocytes. 1. The agglutination, fluorescent antibody and immunodiffusion techniques. 2. The complement fixation and antiglobulin consumption techniques. Attempts were made to detect porcine thrombocyte antibodies by three techniques. No antibodies were detected by immunodiffusion; hetero-antibodies were detected by both the fluorescent antibody and thrombo-agglutination techniques; but iso-antibod...

Burgess, S.C.; Baaten, B.J.G.; Young, J.R.; Davison, T.F., 2000: A monoclonal antibody that recognises the chicken homologue of CD30, a tumour antigen in Mareks disease. Immunology 101(Supplement 1): 27, December

Zhang, T.; Cheng, T.; Wei, L-Hua.; Zhang, Y-Li.; Wang, Y-Bing.; Cai, Y-Jun.; Zhang, J.; Xia, N-Shao., 2010: Construction of highly effective artifical miRNA targeted to HIV-1 vif and the lentiviral-mediated antiviral research in vitro. Effective and specific RNA interference (RNAi) elements are essential for the RNAi-based anti-HIV-1 research which has achieved extensive application. vif37 targeted to HIV-1 vi f is a highly effective and conserved RNAi target obtained from the p...

Petri, R.M.; Schwaiger, T.; Penner, G.B.; Beauchemin, K.A.; Forster, R.J.; McKinnon, J.J.; McAllister, T.A., 2013: Changes in the rumen epimural bacterial diversity of beef cattle as affected by diet and induced ruminal acidosis. Little is known about the nature of the rumen epithelial adherent (epimural) microbiome in cattle fed different diets. Using denaturing gradient gel electrophoresis (DGGE), quantitative real-time PCR (qPCR), and pyrosequencing of the V3 hypervaria...

Marshall, GA., 1974: Dynamics of a small stream affected by waste discharges with emphasis on fish and benthic macroinvertebrate populations. Dissertation Abstr lnt, 349: 4487-4488

Heyting, C.; Van der Laken, C.J.; Raamsdonk, W.V.; Pool, C.W., 1983: Immunohistochemical detection of O6-ethyldeoxyguanosine in the rat brain after in vivo applications of N-ethyl-N-nitrosourea. An immunohistochemical procedure was developed which allows the localization of the DNA lesion O6-ethyldeoxyguanosine (O6-EtdGuo) within tissues and organs. The method permits the detection of 24,000 residues of O6-EtdGuo per diploid nucleus. We h...

Emeryk, A.; Postepski, J.; Gornicka, G.; Barycki, J.; Kawiak, G.; Pisiewicz, K., 1996: Epidemiological study of allergic rhinitis among schoolchildren from urban and rural region. Allergy (Copenhagen) 51(SUPPL 31): 121-122

Mullin, C.A.; Hammock, B.D., 1980: A rapid radiometric assay for mammalian cytosolic epoxide hydrolase. A rapid and sensitive radiometric assay for cytosolic epoxide hydrolase is described. The assay is based on the highly efficient partitioning of unreacted 1-phenyl-1,2-epoxybutane (.beta.-ethylstyrene oxide) from an aqueous mix into isooctane, wit...

Vigorov, Li, 1977: Introduction of new fruit and berry plants to the Central Urals. Trudy Instituta ekologii rastenii i zhivotnykh: 5-49