geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Quantitative CT analysis of pulmonary ground-glass opacity nodules for distinguishing invasive adenocarcinoma from non-invasive or minimally invasive adenocarcinoma: the added value of using iodine mapping


, : Quantitative CT analysis of pulmonary ground-glass opacity nodules for distinguishing invasive adenocarcinoma from non-invasive or minimally invasive adenocarcinoma: the added value of using iodine mapping. European Radiology 26(1): 43-54

To determine whether quantitative analysis of iodine-enhanced images generated from dual-energy CT (DECT) have added value in distinguishing invasive adenocarcinoma from non-invasive or minimally invasive adenocarcinoma (MIA) showing ground-glass nodule (GGN). Thirty-four patients with 39 GGNs were enrolled in this prospective study and underwent DECT followed by complete tumour resection. Various quantitative imaging parameters were assessed, including virtual non-contrast (VNC) imaging and iodine-enhanced imaging. Of all 39 GGNs, four were adenocarcinoma in situ (AIS) (10 %), nine were MIA (23 %), and 26 were invasive adenocarcinoma (67 %). When assessing only VNC imaging, multivariate analysis revealed that mass, uniformity, and size-zone variability were independent predictors of invasive adenocarcinoma (odds ratio [OR] = 19.92, P = 0.02; OR = 0.70, P = 0.01; OR = 16.16, P = 0.04, respectively). After assessing iodine-enhanced imaging with VNC imaging, both mass on the VNC imaging and uniformity on the iodine-enhanced imaging were independent predictors of invasive adenocarcinoma (OR = 5.51, P = 0.04 and OR = 0.67, P < 0.01). The power of diagnosing invasive adenocarcinoma was improved after adding the iodine-enhanced imaging parameters versus VNC imaging alone, from 0.888 to 0.959, respectively (P = 0.029). Quantitative analysis using iodine-enhanced imaging metrics versus VNC imaging metrics alone generated from DECT have added value in distinguishing invasive adenocarcinoma from AIS or MIA. Quantitative analysis using DECT was used to distinguish invasive adenocarcinoma. Tumour mass and uniformity were independent predictors of invasive adenocarcinoma. Diagnostic performance was improved after adding iodine parameters to VNC parameters.

US$19.90

PMID: 25981222

DOI: 10.1007/s00330-015-3816-y


Other references

L.Y.Yu, 1985: Paper chromatographic separation of As, P, and Si, and analysis of chernovite in micro-amounts. The paper chromatographic method was used to separate As, P and Si from one another. A developer butyl acetone: methylisobutyl acetone: hydrofluoric acid: nitric acid=10:10:4:1 was selected. The R (sub f) values were 0.75, 0.4 and zero for As, P a...

Thorn, W.; Raczkowski, H.A., 1952: The course of in situ anaerobic glycolysis measured in rabbit brain at various body temperatures. The anerobic glycolysis of rabbit brain at body temp. of 26[degree], 30[degree] and 38[degree]C was investigated by direct estimation of lactic acid (LA). Prior to the increase of LA there is an induction time which is inversely dependent on the t...

Wallis, G.C., 1939: Further studies on the vitamin D deficiency of mature dairy cows. Cows fed on lucerne hay and grain showed 1.25 to 1.50 I.U. of vitamin D per ml. of blood plasma, whereas cows markedly deficient in vitamin D showed only traces in the blood plasma. Cows producing 60 to 65 1b. of milk per day showed vitamin D defi...

Thomsen, Du, 1977: Veterinary Directorate approved version of the Stomacher method for trichina control. i. the method is used for routine trichina control, particularly in regions where Infestations rarely occur. iI. the method is used for identifying infested pigs within a test group (Trichinella spiralis, parasitic worms, food contamination. Dansk veterinaertidsskrift: 60 (8) 337-341

Proctor, B.; Fairhurst, D., 1993: Identification forum: the Scottish crossbill problem. Birding World. April; 64: 145-146

Kempes, C.P.; Breshears, D.D.; Fessenden, J.E.; Heikoop, J.M., 2003: Variation in carbon isotope ratios in Pinus edulis trees following drought-induced mortality. Ecological Society of America Annual Meeting Abstracts 88: 178

Weed, S.E.; Kantor, L.M.; Haffner, D.W., 1996: Opposing opinions on abstinence programs for adolescents. Journal of Pediatric and Adolescent Gynecology 9(3): 165-168

Nicholls, G.E., 1944: The Phreatoicoidea II The Phreatoicidae Papers and Proc. For this family, a key is given to 10 genera, classified in 3 subfamilies; 40 spp. and subspp. are fully described and figured, all but Phreatoicus typicus Chilton are new or represent new combinations. Subfamily Phreatoicinae: Phreatoicus orarii*...

McIntyre A.; Yarusinsky M.; Molfino B., 1996: Equatorial Atlantic millennial-scale signals of oceanographic climate proxies are in phase with Antarctic ice and lead Greenland ice signals. Eos, Transactions, American Geophysical Union 77(46, Suppl

Carchini, G.; Della-Bella, V.; Solimini, A.G.; Bazzanti, M., 2007: Relationships between the presence of odonate species and environmental characteristics in lowland ponds of central Italy. A set of 21 ponds was sampled three times for odonate larvae during spring 2002. At the same time 17 environmental variables were recorded including area, wet phase duration, total nitrogen, total phosphorus, aquatic macrophytes and land use. A t...