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Racemic total synthesis of dactyloidin and demethyldactyloidin through the DL-proline-catalyzed Knoevenagel condensation/[4 + 2] cycloaddition cascade


, : Racemic total synthesis of dactyloidin and demethyldactyloidin through the DL-proline-catalyzed Knoevenagel condensation/[4 + 2] cycloaddition cascade. Organic & Biomolecular Chemistry 13(39): 9977-9983

An efficient approach towards the first racemic total synthesis of dactyloidin (2) and demethyldactyloidin (3) is described. Their oxygen-bridged tricyclic ketal systems were rapidly constructed by using a remarkable biomimetic Knoevenagel condensation/[4 + 2] cycloaddition cascade as the critical strategy and the 1,5-dicarbonyl segment was assembled by Grignard addition.

US$19.90

PMID: 26287502

DOI: 10.1039/c5ob01636c


Other references

Rone, V.M., 1987: Clonal selection of spruce. Details are given of the performance of the clonal progenies of Picea abies selected by phenotype using a method already described. The first plantings of these clonal progenies are now 10-12 yr old. Results show that the ecological provenance can...

Lui, V.C.H.; Tam, P.K.H.; Leung, M.Y.K.; Lau, J.Y.B.; Chan, J.K.Y.; Chan, V.S.F.; Dallman, M.; Cheah, K.S.E., 2003: Mammary gland-specific secretion of biologically active immunosuppressive agent cytotoxic-T-lymphocyte antigen 4 human immunoglobulin fusion protein (CTLA4Ig) in milk by transgenesis. A major challenge in the field of transplantation is to prevent graft rejection and prolong graft survival. Tolerance induction is a promising way to achieve long-term graft survival without the need for potent immunosuppression and its associated...

Maleci, L.B.ni; Lippi, M.M.riotti; Vannuzzi, M., 1993: The Santa Maria Nuova herbarium housed in the Botanical Museum of Florence. Webbia 48(0): 137-143

Lal, G.M.; Mudgal, V.D., 1972: Nutritional and seasonal effects on the solids-not-fat content of milk of Tharparkar cows. In each of 3 Latin square trials, in winter from November to April, summer from April to July, and the hot, humid season from July to November, in Haryana, 9 Tharparkar cows were given 125, 100 or 75% of total digestible nutrient (TDN) requirement...

Singh, S.P.; Adeloye, A., 1971: Hearing loss in missile head injuries. Journal of Laryngology and Otology 85(11): 1183-1187

Estrada González, L., 1974: The pancreas in the history of surgery. Revista Espanola de Las Enfermedades del Aparato Digestivo 42(4): 451-464

Wolf, S.A.; Hertzler, J.H.; Philippart, A.I., 1980: Cystic adenomatoid dysplasia of the lung. Cystic adenomatoid dysplasia of the lung is an unusual lesion, only 142 cases having been reported in the English literature by 1979. This review describes 32 additional previously unreported patients treated at our institution. The male:female ra...

Frick, R., 2000: PE colour stretch films for silage bales. The suitability of colour polyethylene (PE) stretch films for wrapping silage bales was investigated. Four types of films (white, black, olive green and brown) from 2 different manufacturers (Silotite and Teno-Spin) were used. We investigated the...

Anonymous, 1994: Clinton's Health Security Act recognizes value of nutrition: an update on the legislative debate over health care reform. If passed, President Clinton's new Health Security Act would make nutrition assessment and treatment available to U.S. citizens as part of their package of basic health care benefits. Summaries of the nutrition components and status of this a...

Purschke, G., 1986: Ultastructure of the nuchal organ in the interstitial polychaete Stygocapitella subterranea (Parergodrilidae). Zoologica Scripta, 151: 13-20