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Randomized Crossover Comparison of the Short-Term Efficacy and Safety of Single Half-Dose Silodosin and Tamsulosin Hydrochoride in Men With Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

, : Randomized Crossover Comparison of the Short-Term Efficacy and Safety of Single Half-Dose Silodosin and Tamsulosin Hydrochoride in Men With Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia. Lower Urinary Tract Symptoms 8(1): 38-43

To compare the efficacy and safety of single half-dose silodosin and single full-dose tamsulosin in Japanese men with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH). Japanese men aged ≥50 years with LUTS/BPH and an International Prostate Symptom Score (IPSS) of ≥8 were enrolled in the randomized crossover study and divided into silodosin-preceding (S-T) and tamsulosin-preceding (T-S) groups. The S-T group received 4 mg silodosin once daily for 4 weeks followed by 0.2 mg tamsulosin once daily for 4 weeks. The T-S group received the reverse treatment sequence. A washout period prior to drug crossover was not included. Subjective and objective efficacy parameters including IPSS, quality of life (QOL) index, uroflowmetry, and safety were compared between the two groups. Thirty of 34 men (S-T group n = 16; T-S group n = 14) completed the study. Both drugs significantly improved all IPSS items and QOL index in the first treatment period. Subjective improvement in nocturia by silodosin was observed in both the first and crossover treatment periods. Objective improvement in maximum flow rate by silodosin was only observed in the first treatment period. Adverse events occurred more frequently with silodosin than with tamsulosin; however, none of the adverse events required treatment discontinuation. Ejaculation disorders occurred in three participants (10%) and were associated with silodosin use. Single half-dose silodosin has a similar efficacy to full-dose tamsulosin in Japanese men with LUTS/BPH and thus, may represent an effective, safe, and affordable treatment option.


PMID: 26789541

DOI: 10.1111/luts.12106

Other references

Vereshchagin, I.P.; Zolotarev, A.V.; Kuznetsov, D.I., 1996: Factors of risk of the polyorgan failure syndrome in destructive pancreatitis. The role of neutrophil leukocytes in the development of the polyorgan failure syndrome during an unfavorable course of destructive pancreatitis is discussed. The examinations of 52 patients demonstrated a high correlation of neutrophil functional...

Saltveit, Me, 1999: Effect of ethylene on quality of fresh fruits and vegetables. Ethylene is a naturally occurring plant growth substance that has numerous effects on the growth, development and storage life of many fruits, vegetables and ornamental crops at microliter 1(-1) concentrations. Harvested fruits and vegetables may...

Karmanova, I.G.; Khomutetskaia, O.E.; Shilling, N.V., 1981: Comparative physiologic analysis of the evolutionary stages of sleep and its regulatory mechanisms. Uspekhi Fiziologicheskikh Nauk 12(2): 3-19

Solin, L.J., 2011: Tailored local-regional treatment for early-stage breast cancer. Clinical Breast Cancer 10(5): 343-344

Evans, D.H., 1967: Sodium, chloride and water balance of the intertidal teleost, Xiphister atropurpureus. 3. The roles of simple diffusion, exchange diffusion, osmosis and active transport. Journal of Experimental Biology 47(3): 525-534

Ali, M.A.ub; Singh, W.J.ykumar; Devi, L.I.aotombi; Devi, S.K.njeshwori; Singh, L.R.pachandra, 2007: Isozymic forms of NADP(+)-isocitrate dehydrogenase in germinating seeds of blackgram, Vigna mungo (L.) Hepper. NADP-dependent isocitrate dehydrogenase was extracted and purified from 48 old germinated blackgram, Vigna mungo (L.) Hepper by a procedure including successive purification steps of homogenization, heat treatment, ammonium sulphate fractionation...

William, G., 1963: On a new spasmo-analgesicin general practice. Medizinische Monatsschrift 17: 104-106

Cherry, M.; Hilgert, I.; Kandutsch, A.A.; Snell, G.D., 1970: Effects of proteolytic enzymes on murine H-2 antigens. Transplantation Proceedings 2(1): 48-58

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