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Resokaempferol-mediated anti-inflammatory effects on activated macrophages via the inhibition of JAK2/STAT3, NF-κB and JNK/p38 MAPK signaling pathways


, : Resokaempferol-mediated anti-inflammatory effects on activated macrophages via the inhibition of JAK2/STAT3, NF-κB and JNK/p38 MAPK signaling pathways. International Immunopharmacology 38: 104-114

The excessive or prolonged production of inflammatory mediators can result in numerous chronic diseases, such as rheumatoid arthritis, atherosclerosis, diabetes, and cancer. Therefore, for many inflammatory-related diseases, pharmaceutical intervention is required to restrain the excessive release of such inflammatory mediators. Novel therapeutics and mechanistic insight are sought for the management of chronic inflammatory diseases. Resokaempferol (RES) is a type of flavonoid recently reported to demonstrate anti-cancer properties. However, the anti-inflammatory capacity of RES has not been studied to date. Therefore, this study investigated whether RES is capable of suppressing the inflammatory response to lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and the mechanism by which this is achieved. We found that RES attenuated the LPS-induced production of nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), monocyte chemotactic protein 1 (MCP-1) and IL-6. RES also inhibited the nuclear translocation of signal transducer and activator of transcription (STAT) 3 and reduced the LPS-mediated phosphorylation of Janus kinase (JAK) 2 and STAT3 at the sites of Ser727 and Tyr705. RES also inhibited the activation of NF-κB and JNK/p38 MAPK signaling pathways in LPS-induced RAW264.7 cells. Additionally, RES inhibited the activation of the JAK2/STAT3 pathway in exogenous IL-6-activated RAW264.7 macrophages. We conclude that RES inhibits the inflammatory response in activated macrophages by blocking the activation of the JAK2/STAT3 pathway by both LPS and IL-6 signaling.

US$19.90

PMID: 27261558

DOI: 10.1016/j.intimp.2016.05.010


Other references

Mori, T.; Johnson, C.H., 2000: Circadian control of cell division in unicellular organisms. Cell division cycles and circadian rhythms are major periodic phenomena in organisms. Circadian oscillators control biochemical, physiological, and behavioral events in a wide range of living systems including almost all eukaryotes that have been...

Perera, T.; Wijesuriya, R., E.; Suraweera, P.H.R.; Wijewardene, K.; Kumarage, S., K.; Ariyaratne, M.H.J.; Deen, K., I., 2008: The prevalence of colorectal cancer and survival in patients from the Gampaha District, North Colombo region. Introduction The prevalence and survival of colorectal cancer in Sri Lankans has not been previously reported. We did a retrospective and a prospective survey, in the region of North Colombo, Sri Lanka between 1992 and 2004. The aim was to study...

Fonseca, Fda., 1948: A monograph of the genera and species of Macronyssidae Oudemans,1936synom Liponissidae Vitzthum, 1931 acari. Proceedings of the Zoological Society of London, 1182: 249-334

Marder, V.J., 1997: How have trials of thrombolytics influenced clinical management of patients with acute myocardial infarction. Thrombosis and Haemostasis 78(1): 548-552

Wogensen, L.; Ma, Y.H.i; Grodsky, G.M.; Robertson, R.P.ul; Burton, F.; Sutcliffe, J.G.egor; Sarvetnick, N., 1993: Functional effects of transgenic expression of cholera toxin in pancreatic beta-cells. Investigation of intracellular pathways of stimulus-secretion signaling in vivo is possible by transgenic expression of agents known to influence specific biochemical interactions in the cells. The objective of the present study was to establish a...

Yoo, S.S.; Guttmann, C.R.; Zhao, L.; Panych, L.P., 1999: Real-time adaptive functional MRI. Adaptively limiting image acquisition to areas of interest will allow more efficient data acquisition time for in-depth characterization of areas of brain activation. We designed and implemented an adaptive image acquisition scheme that uses a mul...

Stern, W.E., 1988: Scholarship in the neurosurgical literature. Journal of Neurosurgery 68(6): 986-987

Voulgaridou, P.; Stergiou, K., I., 2003: Trends in various biological parameters of the European sardine, Sardina pilchardus (Walbaum, 1792), in the Eastern Mediterranean Sea. In this study we present the longest time series available concerning various biological parameters of sardine in Greek waters. Biweekly samples were collected within a single day in clusters from random collections of the total landed catch deriv...

Mckeon, G.; Rickert, K.; Scattini, W., 1986: Tropical pastures in the farming system: case studies of modelling integration through simulation. Occasional ication: ) 92-100

Barile, M.F.; Malizia, W.F.; Riggs, D.B., 1962: Incidence and detection of pleuropneumonia-like organisms in cell cultures by fluorescent antibody and cultural procedures. Barile, Michael F. (National Institutes of Health, Bethesda, Md.), Walter F. Malizia, and Donald B. Riggs. Incidence and detection of pleuropneumonia-like organisms in cell cultures by fluorescent antibody and cultural procedures. J. Bacteriol. 84...