geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Retrospective analysis of parkinsonian patients exhibiting normal (123)I-MIBG cardiac uptake


, : Retrospective analysis of parkinsonian patients exhibiting normal (123)I-MIBG cardiac uptake. Journal of the Neurological Sciences 359(1-2): 236-240

Although most patients with Parkinson's disease (PD) show decreased cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake, some exhibit normal uptake. We evaluated the clinical characteristics of such patients. We enrolled 154 non-demented patients showing parkinsonism with normal cardiac MIBG uptake and had been clinically followed up during 29.9 ± 27.6 months. We defined the patients who did not fit the exclusion criteria for PD and demonstrated ≥ 30% reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score after anti-Parkinson agent administration as probable PD. We compared clinical characteristics and the cardiac MIBG heart-to-mediastinum (H/M) ratio between the probable PD group (N=37) and other groups (N=117). The probable PD group showed significantly higher UPDRS motor scores and greater incidence of tremor/rigidity than those of other groups. In addition, they showed a significantly lower cardiac MIBG H/M ratio in the delayed phase (delayed, p<0.0001). Washout-rate (WR) was significantly higher in probable PD cases (p<0.0001). Among 16 probable PD patients undergoing serial cardiac MIBG scintigraphy, the delayed phase cardiac MIBG H/M ratio showed a significant decrease and WR significantly increased during follow-up periods. An increase in WR and lower delayed phase cardiac MIBG uptake were found to be characteristics of such patients.

US$19.90

PMID: 26671120

DOI: 10.1016/j.jns.2015.10.059


Other references

Silver, P.A.; Brent, R.; Ptashne, M., 1986: DNA binding is not sufficient for nuclear localization of regulatory proteins in Saccharomyces cerevisiae. We showed by immunofluorescence that the prokaryotic DNA-binding protein LexA and a chimeric protein that contains the DNA-binding portion of LexA (amino acids 1 to 87) and a large portion (amino acids 74 to 881) of the Saccharomyces cerevisiae po...

Eisig, Hugo., 1869: Beitrage zur Anatomie und Entwicklungsgeschichte der Geschlechtsorgane von Lymnaeus. Zeitschrift fuer Wissenschaftliche Zoologie, XIX 297-320

Anonymous, 2001: Prevention of mother-infant HIV transmission. Thailand, 1998-2000. Part I. Releve Epidemiologique Hebdomadaire 76(33): 253-255

Kamath, M.L.; Matysik, L.S.; Schmidt, D.H.; Smith, L.L., 1985: Sequential internal mammary artery grafts. Expanded utilization of an ideal conduit. The internal mammary artery, when used as a conduit for coronary artery bypass, offers a better long-term patency rate and survival rate than the saphenous vein; however, its utility has been limited. Among other factors, the availability of only...

Teichert, H.; Dötterl, S.; Zimma, B.; Ayasse, M.; Gottsberger, G., 2009: Perfume-collecting male euglossine bees as pollinators of a basal angiosperm: the case of Unonopsis stipitata (Annonaceae). Pollination of Unonopsis stipitata (Annonaceae) by males of two perfume-collecting bees, Euglossa imperialis and Eulaema bombiformis (Euglossini) is described. This is the first detailed account of this pollination mode in a member of a basal angi...

Lemonius, M., 1999: Quality and supply of vegetable seed. Results of a survey carried out by the Seed Division of Thailand's Department of Agricultural Extension in 1993 are discussed. The purpose of the survey was to investigate the quality of seed; the survey included 41 brands from 30 seed produc...

Doyle, D.; Copeland, H.Liesel.; Bush, D.; Stein, L.; Thompson, S., 2011: A course for nurses to handle difficult communication situations. A randomized controlled trial of impact on self-efficacy and performance. to evaluate the impact of a communication skills course for nurses on how to handle difficult communication situations in their daily work. a 7-h course was developed using a construct of "Awareness, Feelings, Listen, Solve" (AFLS). A pe...

Mishra M.D.; Niazi F.R.; Jain R.K., 1990: Serological relationship of rice tungro spherical virus and bacilliform virus components associated with rice tungro disease. Immunosorbent electron microscopy revealed a degree of serological relationship between rice tungro spherical virus and bacilliform virus indicating the existence of some common epitopes on the capsid protein of the two particles.

Fletcher, D.J.; Webby, K., 1977: Observations on gyr falcons falco rusticolus in northeast greenland. A pair of gyr falcons bred in 1974 in the Tunnelelv gorge near Mestersvig and 3 young fledged successfully by July 27th. The plumage of the male parent was paler than that of the female whereas the plumage of the 3 juveniles was heavier and browne...

Yang, J.H.; Rhim, J.S., 1995: 2,3,7,8-Tetrachlorodibenzo-p-dioxin: molecular mechanism of carcinogenesis and its implication in human in vitro model. Critical Reviews in Oncology/Hematology 18(2): 111-127