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Role of terminal and anastomotic circulation in the patency of arteries jailed by flow-diverting stents: animal flow model evaluation and preliminary results


, : Role of terminal and anastomotic circulation in the patency of arteries jailed by flow-diverting stents: animal flow model evaluation and preliminary results. Journal of Neurosurgery 125(4): 898-908

NlmCategory="UNASSIGNED">OBJECTIVE The authors describe herein the creation of an animal model capable of producing quantifiable data regarding blood flow rate and velocity modifications in terminal and anastomotic types of cerebrofacial circulation. They also present the preliminary results of a translational study aimed at investigating the role of terminal and anastomotic types of circulation in arterial branches jailed by flow-diverting stents as factors contributing to arterial patency or occlusion. METHODS Two Large White swine were used to validate a terminal-type arterial model at the level of the right ascending pharyngeal artery (APhA), created exclusively by endovascular means. Subsequently 4 Large White swine, allocated to 2 groups corresponding to the presence (Group B) or absence (Group A) of terminal-type flow modification, underwent placement of flow-diverting stents. Blood flow rates and velocities were quantified using a dedicated time-resolved 3D phase-contrast MRA sequence before and after stenting. Three months after stent placement, the stented arteries were evaluated with digital subtraction angiography (DSA) and scanning electron microscopy (SEM). Patent (circulating) ostia quantification was performed on the SEM images. RESULTS Terminal-type flow modification was feasible; an increase of 75.8% in mean blood velocities was observed in the right APhAs. The mean blood flow rate for Group A was 0.31 ± 0.19 ml/sec (95% CI -1.39 to 2.01) before stenting and 0.21 ± 0.07 ml/sec (95% CI -0.45 to 0.87) after stenting. The mean blood flow rate for Group B was 0.87 ± 0.32 ml/sec (95% CI -1.98 to 3.73) before stenting and 0.76 ± 0.13 ml/sec (95% CI -0.41 to 1.93) after stenting. Mean flow rates after stenting showed a statistically significant difference between Groups A and B (Welch test). Mean and maximal blood velocities were reduced in Group A cases and did not decrease in Group B cases. Control DSA and SEM findings showed near occlusion of the jailed APhAs in both cases of anastomotic circulation (mean patent ostium surface 32,776 μm2) and patency in both cases of terminal-type circulation (mean patent ostium surface 422,334 μm2). CONCLUSIONS Terminal-type arterial modification in swine APhAs is feasible. Sufficient data were acquired to perform an a priori analysis for further research. Flow diversion at the level of the APhA ostium resulted in significant stenosis in cases of anastomotic circulation, while sufficient patency was observed in terminal-type circulation.

US$19.90

PMID: 26771853

DOI: 10.3171/2015.8.JNS151296


Other references

Biggar Gordon M., 1981: Na (sub 2) O mobility in one atmosphere quench furnaces. Progress in Experimental Petrology 5: 89-90

Sandell, R.; Kimber, B.; Andersson, M.; Elg, M.; Fhärm, L.; Gustafsson, N.; Söderbaum, W., 2012: Psychometric analysis of a measure of socio-emotional development in adolescents. This is a psychometric analysis of an instrument to assess the socio-emotional development of school students, How I Feel (HIF), developed as a situational judgment test, with scoring based on expert judgments. The HIF test was administered in gra...

Fletcher, E.L., 2010: Mechanisms of photoreceptor death during retinal degeneration. The development of treatments that slow photoreceptor death could profoundly improve patient wellbeing in those with inherited retinal degenerations. Over recent years, it has emerged that extracellular adenosine-tri-phosphate (ATP) regulates the...

Falk, R.H., 2004: Reconsidering combined antiplatelet and anticoagulant therapy in atrial fibrillation. Heart failure with a normal ejection fraction (HFNEF) predominantly afflicts older, female individuals and is considered to be a consequence of diastolic dysfunction. Doppler echocardiography has become the standard method for identifying and char...

Grollemund, B.; Rinkenbach, R., 2015: Seniors and orthodontics: from denial to a reasonable choice. When patients older than 60 decide to undergo orthodontic treatment, their motivation is not merely for esthetic purposes; it is also intended to preserve their biological capital. Their treatment is often complicated. The orthodontist has to take...

Pena, Enrique A., 1963: Rural leases and co-operatives. Analysis of the legal possibilities of setting up tenancy co-operatives with the main purpose of renting land to be farmed co-operatively by the members. Argentine legislation does not make provisions for this type of co-operation. The author desc...

Niesen, W.D.; Sliwka, U.; Lingnau, A.; Noth, J., 2007: Cerebral emboli in cryptogenic ischemia: a reason to enforce diagnostic testing. Stroke of unknown origin is a diagnostic and therapeutic challenge. A subgroup-analysis was performed to evaluate microembolus detection in these cryptogenic strokes. In this study, 78 patients with acute cerebral ischemia in the anterior circulat...

Nota P.; Moro D.; Sarti R., 1984: Primitive malignant lymphomas of the thyroid diagnostic difficulties and therapeutic problems. Rivista Generale Italiana di Chirurgia 35(2): 83-94

Kopf W., 1983: Investigations of the dynamic of chlorophyll concentration in natural populations of phyto plankton. Measurements of the chlorophyll concentration are usually performed to estimate the biomass of phytoplankton. Seasonal variations of the chlorophyll content per cell are well known. But in productive populations of phytoplankton there are even diu...

Funari, V.A.; Voevodski, K.; Leyfer, D.; Yerkes, L.; Cramer, D.; Tolan, D.R., 2010: Quantitative gene expression profiles in real time from expressed sequence tag databases. An accumulation of expressed sequence tag (EST) data in the public domain and the availability of bioinformatic programs have made EST gene expression profiling a common practice. However, the utility and validity of using EST databases (e.g., dbE...