+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Routine use of a protease zymogen-based colorimetric assay for the detection of Beta-glucan and its role in clinical practice

, : Routine use of a protease zymogen-based colorimetric assay for the detection of Beta-glucan and its role in clinical practice. International Journal of Immunopathology and Pharmacology 27(4): 661-668

The detection of Aspergillus antigen (galactomannan) is considered a reliable marker for the diagnosis of invasive aspergillosis (IA), yet the sensibility and specificity of the assays commonly employed in routine are not optimal. The aim of the present study was to investigate whether the detection of another panfungal antigen, the (1,3)-b-D-glucan could have an auxiliary role in the identification of patients with IA. The study was carried out on 63 sera belonging to patients who had been screened for galactomannan, according to the clinical suspect of IA. Our data show that the positive galactomannan results were not confirmed by positive (1,3)-b-D-glucan results in patients receiving therapy with beta-lactam antibiotics associated with tazobactam, whereas in all the other cases, with the exception of four, the results of the (1,3)-b-D-glucan test were confirmatory of the galactomannan results.


PMID: 25572748

Other references

Miyajima, H.; Takahashi, Y.; Kamata, T.; Shimizu, H.; Sakai, N.; Gitlin, J.D., 1997: Use of desferrioxamine in the treatment of aceruloplasminemia. Aceruloplasminemia is a newly recognized autosomal recessive disorder of iron metabolism resulting in neurodegeneration of the retina and basal ganglia. We report here on the treatment of a patient who developed progressive extrapyramidal symptoms...

Martinez A.E.; Adler Graschinsky E., 1980: Modulatory role of alpha adrenoceptors on the release of tritium labeled norepinephrine elicited by preganglionic stimulation of the cat superior cervical ganglion. In the isolated cat superior cervical ganglion labeled in vitro with [3H]norepinephrine ([3H]NE), the overflow of radioactivity evoked by preganglionic stimulation at 10 Hz (80 V, 2 ms duration for 5 min) was reduced to 50% of control values by th...

Wells, J.M.; Prospero, T.D.; Jenni, L.; le Page, R.W.F., 1987: DNA contents and molecular karyotypes of hybrid Trypanosoma brucei. We have used restriction fragment length polymorphism markers to characterise parental and hybrid trypanosome stocks. Unexpected differences in the intensities of Southern hybridisation banding patterns led us to suspect that the hybrid organisms...

Lund Hoie, K., 1983: The influence of temperature on the phytotoxic effect of glyphosate on Norway spruce (Picea abies L.). The tolerance of 15-month-old Norway spruce plants to glyphosate depended on the temp. not only at the time of application, but also during the 3-4 days after application. High temp. at the time of application, or within the 3-4 days after applica...

Douglass, E.C.; Magrath, I.T.; Lee, E.C.; Whang-Peng, J., 1980: Cytogenetic studies in non-African Burkitt lymphoma. A particular translocation between chromosomes 8 and 14 has been found repeatedly in cytogenetic studies of Burkitt lymphoma, both of African and non-African origin. We report here our findings in cytogenetic studies of direct tumor preparations f...

Fohlman, J.; Pauksen, K.; Hyypiä, T.; Eggertsen, G.; Ehrnst, A.; Ilbäck, N.G.; Friman, G., 1996: Antiviral treatment with WIN 54 954 reduces mortality in murine coxsackievirus B3 myocarditis. Background: Coxsackieviruses B (CBVs) are dominant causative agents in myocarditis and are associated with pathogenesis in some cases of dilated cardiomyopathy, a clinical entity with a poor survival without heart transplantation. Methods and Resu...

Hosny, M.; Said, W., 1980: The nesting system and the chemical structure of the material coating the internal parts of the nests of Anacanthotermes ochraceus in Egypt. Sociobiology (2): 101-114

Butterfield, W.R., 1906: On the occurrence of Puffinus kuhli in Sussex. Bulletin of the British Ornithologists' Club, 16 71

Huang, X.; Deng, R.; Tu, W.; Hu, Z., 2016: Dexmedetomidine reduces neuropathic pain in a rat model of skin/muscle incision and retraction. Dexmedetomidine has been proposed as a novel anesthetic adjuvant. However, it remains unclear whether peripheral administration of dexmedetomidine is safe and effective to reduce acute postoperative pain. This study aimed to examine the effects of...

Zídková, H.; Kolár, J., 1986: Is radiodiagnosis of osteoarticular tuberculosis still an urgent problem?. Ceskoslovenska Radiologie 40(6): 378-387