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Selective Monoarylation of Primary Amines Using the Pd-PEPPSI-IPent(Cl) Precatalyst

, : Selective Monoarylation of Primary Amines Using the Pd-PEPPSI-IPent(Cl) Precatalyst. Angewandte Chemie 54(33): 9507-9511

A single set of reaction conditions for the palladium-catalyzed amination of a wide variety of (hetero)aryl halides using primary alkyl amines has been developed. By combining the exceptionally high reactivity of the Pd-PEPPSI-IPent(Cl) catalyst (PEPPSI=pyridine enhanced precatalyst preparation, stabilization, and initiation) with the soluble and nonaggressive sodium salt of BHT (BHT=2,6-di-tert-butyl-hydroxytoluene), both six- and five-membered (hetero)aryl halides undergo efficient and selective amination.


PMID: 26097000

DOI: 10.1002/anie.201502822

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