geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity


, : Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity. Obesity 23(6): 1226-1233

Excessive weight gain frequently occurs in patients with hypothalamic tumors and lesions leading to hypothalamic obesity (HO). Digital brain magnetic resonance imaging (MRI) and clinical outcomes were studied retrospectively in a single center, including 45 children with postoperative lesions in the sellar region (41 craniopharyngiomas, 4 with Rathke's cleft cysts), āˆ¼5 years post-surgery, mean age 13.9 years. Four standard sections covering hypothalamic areas critical to energy homeostasis were used to assess lesions and calculate a hypothalamic lesion score (HLS); the association with HO was examined. Compared to subjects who did not develop HO (n = 23), subjects with HO (n = 22) showed more frequently lesions affecting the third ventricular floor, mammillary bodies, and anterior, medial (all Pā€‰<ā€‰0.05), and most importantly posterior hypothalamus (P < 0.01). The HLS correlated significantly with BMI z-score changes 12 and 30 months post-surgery, even after adjusting for potential confounders of gender, age at surgery, surgery date, surgery BMI z-score, hydrocephalus, and residual hypothalamic tumor (r = 0.34, P = 0.03; r = 0.40, P = 0.02, respectively). Diabetes insipidus was found to be an endocrine marker for HO risk. The extent of damage following surgery in the sellar region can be assessed by MRI using a novel scoring system for early HO risk assessment.

US$19.90

PMID: 25884561

DOI: 10.1002/oby.21067


Other references

Thibonnier, M.; Bayer, A.L.; Leng, Z., 1993: Cytoplasmic and nuclear signaling pathways of V1-vascular vasopressin receptors. We studied the cytoplasmic and nuclear signaling pathways of V1-vascular AVP receptors of human platelets, primary cultures of renal glomerular mesangial cells, and established cultures of the A7r5 aortic smooth muscle cell line.The immediate tran...

Davidson, N.; Clark, N., 1985: WSG Project on the effects of severe weather on waders: fourth progress report. Wader Study Group Bulletin: 4-5 (43)

Saito, S.; Morino, T.; Masuda, K., 2000: 2,3-disubstituted cyclopentanone derivatives, process for producing the same, and medicinal use thereof. The present invention relates to a compound represented by the following general formula (1) ##STR1## (wherein X represents O, S, SO, SO2, or NH, Y is a substituted or unsubstituted hydrocarbon residue containing 1 through 6 carbon atoms and havin...

Charuruks, N.; Huayhongthong, V.; Srisink, N.; Yangsuk, S.; Dangchen, N.; Pirom, S.; Thaisamsen; Noysri, P., 1997: Evaluation of the reticulocyte count portion of technicon H*3 blood analyzer: lowering the test expense by reducing the reticulocyte reagent. Automated reticulocyte counting has become an essential instrument of the hematology laboratory. This automatic technique has lead to diminishing labour tasks and to significant improvements in accuracy and precision compared with the manual micro...

Kovacs, E.K.ss, I.K.roli, G., 1985: Disinfestation of wheat germ, wheat, and dried mushrooms by irradiation. Radiation disinfestation of food and agricultural products: proceedings of an international conference Honolulu Hawaii November 14-18-1983 edited by James H Moy: 198

Nolte C.J.M.; Oleson M.A.; Bilbo P.R.; Gay R.J.; Parenteau N.L., 1992: The living skin equivalent as a model for studies of barrier function. Journal of Investigative Dermatology 98(4): 582

Droogleever Fortuyn, J., 1952: Consciousness and cerebral cortex. Nederlands Tijdschrift Voor Geneeskunde 96(17): 990-994

Kethley, J.B., 1977: The status of hybalicus and oehserchestes acari acariformes endeostigmata. The status of Hybalicus Berlese 1913 and Hybalicus sensu Theron 1974 are reviewed. The synonymy Hybalicus Berlese (= Loradalychus Grandjean 1939) is justified. The redescription of Oehserchestes Jacot 1939 as Hybalicus sensu Theron 1974 necessitat...

Hu, D.E.; Fan, T.P.D., 1994: Suppression of hepatocyte growth factor-induced angiogenesis by suramin. British Journal of Pharmacology 114(PROC SUPPL ): 400P

Han SuFen; Lin ShuYan; Zheng FuQiang, 2003: The way of rhizobia invading locust. Various changes in black locust [Robinia pseudoacacia] roots were observed by optical microscope after inoculating with rhizobia. There was no deformation in the root hair of seedlings which had not been inoculated with rhizobia. The deformed root...