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Serum adipokines levels in patients with systemic sclerosis: A meta-analysis


, : Serum adipokines levels in patients with systemic sclerosis: A meta-analysis. Modern Rheumatology (): 1-8

Systemic sclerosis is an chronic inflammatory autoimmune diseases. Adipokine has been reported to play an important role in modulating immune responses. Recent studies suggest that adipokine also plays some roles in the pathogenesis of systemic sclerosis (SSc). However, published data regarding the relationship between plasma/serum adipokine levels and SSc are contradictory. The aim of this study was at performing a meta-analysis to derive a more accurate estimation and further investigate the association of plasma/serum leptin and adiponectin levels with SSc patients. PubMed, and Web of Science databases (up to Feb 20, 2016) were used to obtain all relative published literatures. The study quality was assessed by the Newcastle-Ottawa scale. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by random-effect model analysis. A total of fourteen studies were finally included in this meta-analysis. Among them, six of which were studied for the serum adiponectin levels in SSc patients, six of which were studied for the serum leptin levels in SSc patients, and two of them were studied both for serum adiponectin levels and serum leptin levels in SSc patients. The meta-analysis results showed that the serum adiponectin levels in SSc patients were significantly lower than that in normal controls (SMD = -0.608 ng/ml, 95% CI = -1.029 to -0.186, p = 0.005). However, there were no significant differences in serum leptin levels between SSc patients and healthy controls (SMD = -0.990 ng/ml, 95% CI = -2.340 to 0.359, p = 0.150). The subgroup analysis showed that Asia SSc patients with age less than 50 years old had lower plasma/serum adiponectin levels when compared with controls. The serum adiponectin levels, but not serum leptin levels, in SSc patients were significantly lower than that in normal controls.

US$19.90

PMID: 27321124

DOI: 10.1080/14397595.2016.1193106


Other references

Graybiel, A.; White, P.D.; Wheeler, L.; Williams, C., 1952: Electrocardlography in practice. In the preface, it is stated that the main purpose is the production of an atlas, and that the book is not intended to be a textbook. There are nearly 300 figures. Particularly valuable are the serial records and the clinical correlations. Incorpo...

Saw, H.S., 1981: What is an ideal cardioplegic solution?. Some form or other of chemical cardioplegia is used by most cardiac surgeons today as a means of intra-operative myocardial protection. Innumerable clinical papers supporting each of these solutions have emerged but actual experimental evidence of...

Thompson, C.J.; Goertzen, A.L., 2005: A method for determination of the timing stability of PET scanners. We report on the timing resolution and stability of the MicroPET R4 PET scanner. Its detectors have energy resolutions in the range of 25% and previously reported timing resolutions 3.2 ns. Our preliminary evaluation of this instrument showed that...

Gans, C.; Ulinski, PS., 1992: Sensorimotor integration. Biology of the Reptilia, Volume 17, Neurology C. Unknown

Wang, J.; Lai, C.H.; Gu, Y., 2001: Ergodicity and scars of the quantum cat map in the semiclassical regime. We study the quantum localization effect of the cat map manifested in the motions of statistical ensembles. Specifically, the coarse-grained entropy and time-averaged phase space distributions are investigated. For this purpose, an amended version...

Ali, M.; McDonald, J.W.; Thiessen, J.J.; Coates, P.E., 1980: Plasma acetylsalicylate and salicylate and platelet cyclooxygenase activity following plain and enteric-coated aspirin. Compressed and enteric-coated acetylsalicylate (ASA) tablets have been compared in normal healthy subjects. Plasma ASA and salicylate (SA) were measured by high pressure liquid chromatography (HPLC). Platelet cyclooxygenase activity in vitro was s...

Carney, M.W.; Macleod, S.; Sheffield, B.F., 1981: Thyroid function screening in psychiatric in-patients. During a two-year biochemical screening for thyroid disease amongst 191 psychiatric admissions, 38 (20 per cent) had an abnormal result, 5 were hyperthyroid and 7 hypothyroid. Thyroid dysfunction was associated with female sex and affective psycho...

Luo, J.; You, L.; Zhang, J.; Guo, K.; Zhu, H.; Gu, L.; Yang, Z.; Li, X.; Yang, J.; Zhang, W., 2017: Enhanced Average Thermoelectric Figure of Merit of the PbTe-SrTe-MnTe Alloy. Thermoelectric properties of Na-doped PbTe-SrTe system have been improved by the addition of Mn. The substitution of Mn for Pb modifies the band structure of the PbTe-SrTe alloy, which enlarges the band gap and increases the valence band degenerac...

Ide, F.P., 1969: Professor Edmund M. walker, 1877--1969. Can. Fld Nat.: 83: 389-391

Ting, G.; Carrie, B.; Freitas, T.; Zarghamee, S., 1998: Short daily hemodialysis Global ESRD costs. Journal of the American Society of Nephrology 9(PROGRAM AND ABSTR ISSUE): 240A, Sept