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Sevelamer Hydrochloride for Tumor Lysis Syndrome-related Hyperphosphatemia


, : Sevelamer Hydrochloride for Tumor Lysis Syndrome-related Hyperphosphatemia. Indian Pediatrics 52(7): 613-615

Tumour lysis syndrome is associated with high levels of uric acid, phosphate and potassium along with low levels of calcium and abnormal renal function. Sevelamer, an oral phosphate-binder is used in the treatment of hyperphosphatemia in children and adults on hemodialysis. Two children with T-cell acute lymphoblastic leukemia who presented with a high tumour load and developed tumour lysis syndrome. Both children received Rasburicase and Sevelamer hydrochloride. The serum phosphate reduced to normal levels within 24-48 hrs of initiation of sevelamer hydrochloride. Sevelamer appears to be an effective treatment for hyperphosphatemia associated with tumour lysis syndrome.

US$29.90

PMID: 26244958


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