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Sex-Specific Prediction Models for Sleep Apnea From the Hispanic Community Health Study/Study of Latinos

, : Sex-Specific Prediction Models for Sleep Apnea From the Hispanic Community Health Study/Study of Latinos. Chest 149(6): 1409-1418

We developed and validated the first-ever sleep apnea (SA) risk calculator in a large population-based cohort of Hispanic/Latino subjects. Cross-sectional data on adults from the Hispanic Community Health Study/Study of Latinos (2008-2011) were analyzed. Subjective and objective sleep measurements were obtained. Clinically significant SA was defined as an apnea-hypopnea index ≥ 15 events per hour. Using logistic regression, four prediction models were created: three sex-specific models (female-only, male-only, and a sex × covariate interaction model to allow differential predictor effects), and one overall model with sex included as a main effect only. Models underwent 10-fold cross-validation and were assessed by using the C statistic. SA and its predictive variables; a total of 17 variables were considered. A total of 12,158 participants had complete sleep data available; 7,363 (61%) were women. The population-weighted prevalence of SA (apnea-hypopnea index ≥ 15 events per hour) was 6.1% in female subjects and 13.5% in male subjects. Male-only (C statistic, 0.808) and female-only (C statistic, 0.836) prediction models had the same predictor variables (ie, age, BMI, self-reported snoring). The sex-interaction model (C statistic, 0.836) contained sex, age, age × sex, BMI, BMI × sex, and self-reported snoring. The final overall model (C statistic, 0.832) contained age, BMI, snoring, and sex. We developed two websites for our SA risk calculator: one in English ( and another in Spanish ( We created an internally validated, highly discriminating, well-calibrated, and parsimonious prediction model for SA. Contrary to the study hypothesis, the variables did not have different predictive magnitudes in male and female subjects.


PMID: 26836933

DOI: 10.1016/j.chest.2016.01.013

Other references

Dickstein, A., 1951: Uterine sarcoma; incidence. Anais Brasileiros de Ginecologia 32(4): 159-170

Abdel-Latif, A.A.; Brody, J.; Ramahi, H., 1967: Studies on sodium-potassium adenosine triphosphatase of the nerve endings and appearance of electrical activity in developing rat brain. Studies were conducted on the appearance of adenosine triphosphatase (ATPase) in nerve-ending particle fractions, isolated from crude mitochondrial preparations of developing rat brain by discontinuous Ficoll density gradient ultra-centrifugation....

Luebke, A.E.; Foster, P.K.; Muller, C.D.; Peel, A.L., 2001: Cochlear function and transgene expression in the guinea pig cochlea, using adenovirus- and adeno-associated virus-directed gene transfer. Development of a viral vector that can infect hair cells of the cochlea without producing viral-associated ototoxic effects is crucial for utilizing gene replacement therapy as a treatment for certain forms of hereditary deafness. In the present s...

Komitov, R., 1965: The Drianovo early sour cherry. The pomological, biological and economic characteristics of this variety are given. These include ripening in the first half of June, resistance to Monilia, a medium-sized stone separating easily from the pulp, moderate vigour, regular bearing and...

Mackin, R.B.; Raker, V.A.; Spiess, J., 1991: Improved method for identification of proteins using two-dimensional electrophoresis with immobilized pH gradient isoelectric focusing. Recent advances in protein sequence analysis now permit the determination of partial N-terminal and internal primary structure from low picomole quantities of protein. The major remaining hurdles to sequence analysis of small amounts of protein ar...

Barbosa Cisneros, O.; Avalos Diaz, E.; Vera, O.; Moreno, J.; Herrera Esparza, R., 1996: Role of centromere proteins in centromere survival. FASEB Journal 10(6): A1261

Chan, M.Y.; Liao, H.R.; Cheng, F.J., 1989: Traumatic intracorneal cyst. We describe clinical and pathologic characteristics of two cases of traumatic intracorneal cyst. Both patients were children, without a history of ocular surgery, but they had been injured by scissors many years before the corneal lesion was noted...

Ehiro M.; Shimoyama S.; Murata M., 1986: Some permian cyclolobaceae from the southern kitakami massif northeast japan. Five specimens of the Middle to Upper Permian ammonoids, Stacheoceras otomoi, sp. nov., S. sp. and Timorites intermedium (Wanner) are described from the Ogatsu, Utatsu and Okago districts in the Southern Kitakami Massif. Stacheoceras sp. from the...

Grissinger, M., 2015: Look Out for Lugol's: Error-Prevention Strategies for This Strong Iodine Solution. Safety strategies for avoiding tragedies with Lugol's solution.

Li, C.; Wu, L.; Xu, W.; Song, J.; Shi, J.; Yu, P.; Kan, Y.; Wang, H., 2015: Silicon Spiro Double Helicene-like Compounds Based on Dithieno[2,3-b:3',2'-d]thiophene: Syntheses and Crystal Structures. Silicon spiro carbon-sulfur double helicene-like compounds 1 and rac-2 were synthesized from 2,5-bis-trimethylsilanyldithieno[2,3-b:3',2'-d]thiophene, with total yields of 17% and 7%, respectively. (1)H and (13)C NMR spectra and X-ray cr...