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Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice


, : Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice. Experimental Animals 65(1): 97-107

Anxiety and depressive symptoms are generated after paradoxical sleep deprivation (PSD). However, it is not clear whether PSD produces differential effects between females and males. The aim of this study was to assess the effect of PSD on anxiety- and depressive-like behaviors between sexes. Male and female BALB/c mice were divided in three groups: the control group, the 48-h PSD group and the 96-h PSD group. Immediately after PSD protocols, the forced swimming and open field test were applied. Sucrose consumption test was used to evaluate the middle-term effect of PSD. We found that corticosterone serum levels showed significant differences in the 96-h PSD females as compared to 96-h PSD males. In the open-field test, the 48-h and 96-h PSD females spent more time at the periphery of the field, and showed high locomotion as compared to males. In the elevated plus maze, the 48-h PSD females spent more time in closed arms than males, which is compatible with anxiety-like behavior. The forced swim test indicated that the 96-h PSD males spent more time swimming as compared to the 96-h PSD females. Remarkably, the 96-h PSD males had lower sucrose intake than the 96-h PSD females, which suggest that male mice have proclivity to develop a persistent depressive-like behavior late after PSD. In conclusion, male mice showed a significant trend to depressive-like behaviors late after sleep deprivation. Conversely, female have a strong tendency to display anxiety- and depressive-like behaviors immediately after sleep deprivation.

US$19.90

PMID: 26548630

DOI: 10.1538/expanim.15-0054


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Cassar-Pullicino, V.N.; Taylor, D.N.; Fitz-Patrick, J.D., 1985: Multiple metallic mercury emboli. Most tumours grow more slowly when implanted into pre-irradiated sites--the tumour bed effect (TBE). The TBE is usually assayed by measuring the delay for tumours growing in irradiated sites compared with that for tumours growing in mock-irradiate...

Hoek, H.; Sarrazijn, R.; Vanderschelden, C.; Desmet, D.; Vandemeulebroucke, C., 1999: Witloof chicory. Results of cultivar trial of late forcing of witloof chicory 1999: Platine is a welcome addition for late forcing. Six witloof chicory cultivars (Final, MH 2520, Platine, Progressa, Senator and Tabor) were compared in Belgium and the Netherlands. Cultivars were sown in May 1998, harvested in November-December, and stored at -1 degrees C. Forcing was done twice...

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Thompson, D.J.; Eversole, W.J., 1966: The effects of amino-glutethimide on the rat ovary. Proceedings of the Indiana Academy of Science, 75: 285

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Simon, M.R.; Roi, L.D.; Desai, S.; Salberg, D.J.; Rose, N.R., 1983: Comparison of cultures of human lymphocytes obtained following NH4Cl induced red blood cell lysis and Ficoll-Hypaque density gradient centrifugation. Lymphocyte thymidine uptake in leucocytes prepared by NH4Cl induced RBC lysis was compared with that of lymphocytes obtained following Ficoll-Hypaque centrifugation using polynomial regression dose response curves which adjusted for inherent subje...

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