+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Short-term effect of infliximab is reflected in the clot lysis profile of patients with inflammatory bowel disease: a prospective study

, : Short-term effect of infliximab is reflected in the clot lysis profile of patients with inflammatory bowel disease: a prospective study. Inflammatory Bowel Diseases 21(3): 570-578

Inflammatory bowel disease (IBD) is recognized as an independent risk factor for thrombosis. First, we investigate whether the concentration of fibrinolysis inhibitors is increased in patients with IBD. Second, we investigate the effect of infliximab induction therapy on the hemostatic profile. This prospective study included 103 patients with IBD starting infliximab therapy and 113 healthy controls. Plasma was collected before the first infliximab infusion (wk 0) and after induction therapy (wk 14). Patients not showing a clinical response on induction were considered as primary nonresponders. Fibrinolysis inhibitors were measured by enzyme-linked immunosorbent assay. Using a clot lysis assay, the area under the curve (global marker for coagulation/fibrinolysis), 50% clot lysis time (marker for fibrinolytic capacity), and amplitude (indicator for clot formation) were determined. Patients with IBD selected for infliximab treatment have higher area under the curve (median 29 [interquartile range, 20-38]) and amplitude (0.4 [0.3-0.5]) compared with healthy controls (18 [13-24] and 0.3 [0.2-0.3], respectively, P < 0.001). Primary nonresponders showed a decrease neither in inflammatory markers nor in hemostatic parameters, whereas in primary responders, a decrease in inflammatory markers was associated with a decrease in both area under the curve (29 [20-38] (wk 0) to 20 [14-28] (wk 14), P < 0.001) and amplitude (0.4 [0.3-0.5] (wk 0) to 0.3 [0.3-0.4] (wk 14), P < 0.001). This is the first prospective study demonstrating that the clot lysis profile differs between patients with IBD and healthy individuals. On infliximab induction treatment, this clot lysis profile normalizes in responders suggesting that infliximab treatment is advisable for patients with IBD with an activated hemostatic profile.


PMID: 25659086

DOI: 10.1097/MIB.0000000000000301

Other references

Petrányi, G., 1979: Hazards of hyperventilation during diving. Orvosi Hetilap 120(17): 1041-1042

Wallman, E.; Wallman, E., 1940: Thermosensibilite des bacteriophages. The smaller the bacteriophages, the more resistant they are to x-rays, and the more sensitive they are to heat. The temp. required for coagulation of proteins increases with their molecular wt.

Fisher, Stephen, 1948: The behaviour of Haemophilus pertussis in casein in hydrolysate broth. Under favorable conditions, small inocula, e.g., 12 live organisms per cc. of culture, are sufficient to initiate growth in caseinhydrolysate starch broth; multiplication takes place at the rate of about 3 generations a day, and the final yield of...

Schoonmaker, Peter K., 1998: Paleoecological perspectives on ecological scale. Peterson, D L [Editor], Parker, V T [Editor] Complexity in Ecological Systems; Ecological scale: Theory and applications 79-103

Benabdelhak, H.; Schmitt, L.; Horn, C.; Jumel, K.; Blight, M.A.; Holland, I.Barry., 2005: Positive co-operative activity and dimerization of the isolated ABC ATPase domain of HlyB from Escherichia coli. The ATPase activity of the ABC (ATP-binding cassette) ATPase domain of the HlyB (haemolysin B) transporter is required for secretion of Escherichia coli haemolysin via the type I pathway. Although ABC transporters are generally presumed to functio...

Fenner, F., 1952: Vaccination against tuberculosis with B.C.G. vaccine. Medical Journal of Australia 2(22): 767-70; Discussion 785-6

Curtoni, G.; Notarantonio, A.; Pancotti, G.; Feyles, E., 1991: Extracranial cephalic neurogenic tumors. A case report of a schwannoma with a rare location. Following a brief critical review of the latest international literature, the paper describes a case of extracranial cephalic neurogenic tumour in an unusual location. Clinical and anatomo-pathological aspects are assessed and the problems of ther...

Braakman, R., 1957: Prognosis in cases of subarachnoid hemorrhage with conservative therapy. Nederlands Tijdschrift Voor Geneeskunde 101(28): 1313-1318

Hiramatsu, N.H.rschmann, W., 1979: Partial gang system of a new Trichouropoda species from India (Trichouropodini, Uropodinae). Acarologie (25) 35-36

Tanaka, N.; Shinozuka, K., 2005: Function of purinergic endothelial cell shape regulation in vascular permeability. Seikagaku. Journal of Japanese Biochemical Society 77(4): 351-354