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Short-term spontaneous fluctuations of HBV DNA levels in a Senegalese population with chronic hepatitis B

, : Short-term spontaneous fluctuations of HBV DNA levels in a Senegalese population with chronic hepatitis B. Bmc Infectious Diseases 15(): 154-154

We evaluated the short-term spontaneous fluctuations of HBV DNA and HBsAg levels in Senegalese patients with chronic infection with hepatitis B virus and normal ALT and determined factors related to these fluctuations. A total of 87 patients with persistent normal ALT values were enrolled in the study. Serum samples were obtained at three different visits, with an interval of 2 months (M0, M2, and M4), and without initiating anti HBV treatment. Levels of HBV DNA, quantitative HBsAg, ALT and AST, genotyping and viral DNA mutations were analyzed. Among the 87 patients, genotype E was predominant (75%). The median HBV DNA level was 2.9 log10 IU/mL [2.2-3.4], 2.7 log10 IU/mL [2.1-3.6] and 2.7 log10 IU/mL [2.1-3.4] at M0, M2 and M4, respectively. The values ranged from <1.1 to 7 log10 IU/mL and 55 (63%) had HBV DNA fluctuations≥0.5 log10 IU/mL between two visits. Patients in whom HBV DNA fluctuated ≥0.5 log10 IU/mL between M0 and M2 also had significant fluctuations between M2 and M4, while patients with stable HBV DNA between M0 and M2 showed a stable viral load between M2 and M4. The only factor found to be associated with HBV DNA fluctuations≥0.5 log10 IU/mL was a low BMI (<21 kg/ m2). HBsAg levels were not correlated with HBV DNA levels. Sixty-three percent of the enrolled Senegalese population showed a large, short-term fluctuation of HBV DNA levels. Such fluctuations may have an impact on therapeutic management, requiring closer monitoring.


PMID: 25887383

DOI: 10.1186/s12879-015-0881-4

Other references

Shinn G.L., 1980: Reproduction of syndisyrinx franciscanus a flatworm symbiont of sea urchins. American Zoologist 20(4): 892

Ward, R.; Banerjee, A.K.; Lafiandra, A.; Shatkin, A.J., 1971: Reovirus specific rna from polysomes of infected mouse l cells. Journal of Virology 9(1): 61-69

Marcuzzi, G.; Mistrello, P., 1959: The water content of the Tenebrio molitor L. Rivista di Biologia 51: 343-365

Farrell C.; Rest R., 1990: Detection of a human neutrophil receptor for gonococcal outer membrane protein pii. Abstracts of the Annual Meeting of the American Society for Microbiology 90: 109

Gome, O.Ozco, L.; Ortega, H., 1964: Sporotrichosis In A Two-And-One Half-Month-Old Infant. Alergia 12: 26-28

Boczkowski, K., 1969: Genetic and clinical studies in male hermaphroditism. Polish Medical Science and History Bulletin 12(1): 5-12

Pizengol' c, M.Z.; Varava, A.P.; Burgov, P.M.; Stejnman, M.J.; Sorokina, Z.M., 1976: Practical course on book-keeping in agriculture. The book deals with book-keeping practice in Soviet kolkhozy and sovkhozy. Details are presented of the basic principles and practical operation of data processing and accounting of all important monetary and physical activities on the farm, inclu...

Yu, Q.; Mao, W.; Xie, C.; Li, S., 1991: HLA antigens and Vogt-Koyanagi-Harada's disease. Thirty patients with Vogt-Koyanagi-Harada's disease were typed for HLA-A and HLA-B antigenic determinants by a microlymphocytotoxicity technique. HLA-B22 antigen showed an increased frequency of 43.3% in the patient group (relative risk = 8.6...

Webster, D.A., 1975: The formation of hydrogen per oxide during the oxidation of nadh by cytochrome o from vitreoscilla. Journal of Biological Chemistry 250(13): 4955-4958

Jenkin, N., 1957: Effects of varied distance on short-range size judgments. Journal of Experimental Psychology 54(5): 327-331