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Single-Fraction Radiotherapy for CD30(+) Lymphoproliferative Disorders

, : Single-Fraction Radiotherapy for CD30(+) Lymphoproliferative Disorders. Biomed Research International 2015(): 629587-629587

CD30(+) lymphoproliferative disorder is a rare variant of cutaneous T-cell lymphoma. Sustained complete response following first-line treatments is rare. This retrospective review evaluates the response of refractory or recurrent lesions to palliative radiation therapy. The records of 6 patients with 12 lesions, treated with radiation therapy, were reviewed. All patients received previous first-line treatments. Patients with clinical and pathological evidence of symptomatic CD30(+) lymphoproliferative disorder, with no history of other cutaneous T-cell lymphoma variants, and with no prior radiation therapy to the index site were included. The median age of patients was 50.5 years (range, 15-83 years). Median size of the treated lesions was 2.5 cm (range, 2-7 cm). Four sites were treated with a single fraction of 750-800 cGy (n = 3) and 8 sites were treated with 4000-4500 cGy in 200-250 cGy fractions (n = 3). Radiation therapy was administered with electrons and bolus. Median follow-up was 113 months (range, 16-147 months). For all sites, there was 100% complete response with acute grade 1-2 dermatitis. For recurrent and symptomatic radiation-naïve CD30(+) lymphoproliferative disorder lesions, palliative radiation therapy shows excellent response. A single fraction of 750-800 cGy is as effective as a multifractionated course and more convenient.


PMID: 26504818

DOI: 10.1155/2015/629587

Other references

Garcia, M.G.; Torres, R.J.; Puig, J.G., 2010: Methylation status of HPRT1 promoter in HPRT deficiency with normal coding region. Lesch-Nyhan syndrome is an X-linked recessive inborn error of metabolism due to a complete deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity (OMIM 300322). Partial deficiency of HPRT (OMIM 300323) is characterized by the...

Kite, J.H., 1970: Conservative treatment of the resistant recurrent clubfoot. Clinical Orthopaedics and Related Research 70: 93-110

Sinha, R.R.dha, C.P.akash, J.K.ul, P., 2007: Whey protein hydrolysate: Functional properties, nutritional quality and utilization in beverage formulation. The objective of the study was to analyze the functional and nutritional properties of enzymatically hydrolyzed whey protein concentrate (WPC) and to formulate a beverage mix. WPC hydrolysates were produced using fungal protease and papain, at tim...

Marini, M.; Fathi, M.; Vallotton, M., 1994: Determination of serum metanephrines in the diagnosis of pheochromocytoma. Presently, the diagnosis of pheochromocytoma rests upon the determination of urinary catecholamines, and specially metanephrines which offer 100% sensitivity and 97% specificity. The 24 hours urine collection is problematic for practical reasons a...

Benjamin, S.A.; Leichliter, A.K.; Jauregui, J.J.; Elmallah, R., 2016: Poster 136 Meta-Analysis of Non-Operative Modalities in the Treatment of Knee Pain in Osteoarthritis. Pm & R 8(9s): S206-S206

Gordon, D.L.; Erviti, V.; Jun, J.I.; Schwartz, M.A.; Martinez, C.J., 1972: The distribution of serum calcium levels by age and sex in hospitalized patients. Chicago Medical School Quarterly 31(1-4): 14-18

Gorbunov, V.I., 1976: Decubitus ulcers in spinal injuries. Meditsinskaia Sestra 35(12): 48-49

Pregill G., 1984: An extinct species of leiocephalus from haiti sauria iguanidae. At least 5 spp. of the endemic West Indian lizard genus Leiocephalus are known only by fossils excavated from cave deposits in the Greater and Lesser Antilles. Fossils of yet another extinct species were recently found in a crate of matrix that wa...

Løkkegaard, E.; Pedersen, A.T.; Heitmann, B.L.; Jovanovic, Z.; Keiding, N.; Hundrup, Y.A.; Obel, E.B.; Ottesen, B., 2003: Relation between hormone replacement therapy and ischaemic heart disease in women: prospective observational study. Objective: To investigate the risk of ischaemic heart disease and myocardial infarction among women using hormone replacement therapy, especially the potential modifying effect of cardiovascular risk factors. Design: Prospective observational stud...

Geyh M.A.; Kudrass H R.; Streif H., 1979: Sea level changes during the late pleistocene and holocene in the strait of malacca malaysia. Nature (London) 278(5703): 441-443