geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Surgical treatment of ectopic adrenocorticotropic hormone syndrome with intra-thoracic tumor


, : Surgical treatment of ectopic adrenocorticotropic hormone syndrome with intra-thoracic tumor. Journal of Thoracic Disease 8(5): 888-893

The study was to review the clinical manifestations and laboratory examinations of ectopic adrenocorticotropic hormone (ACTH) syndrome, and to analyze the efficacy of surgical treatment. The clinical data, surgical therapy, and outcome of 23 cases of ectopic ACTH syndrome accompanied by intra-thoracic tumors were reviewed. The tumors were removed from all the patients according to the principles of radical resection. The tumors were confirmed as associated with ectopic ACTH secretion in 19 cases. Hyperglycemia and hypokalemia were recovered, while plasma cortisol, plasma ACTH and 24-hour urinary free cortisol (UFC) levels were significantly reduced after surgery in these 19 cases. Recurrences of the disease were found in six cases during following-up, and five of them died. The thoracic cavity should be a focus in routine examinations of patients with symptoms of Cushing's syndrome (CS), because ectopic ACTH-producing tumors are commonly found in bronchus/lung and mediastinum. Despite the incidence of the pulmonary nodule secondary to opportunistic infection in some cases, surgery is still the first choice if the tumor is localized. The surgical procedure should be performed according to the principles in resection of lung cancer and mediastinal tumor. The surgical efficacy is significant for short-term periods; however, the recurrence of the disease in long-term periods is in great part related to distal metastasis or relapse of the tumor.

US$19.90

PMID: 27162663

DOI: 10.21037/jtd.2016.03.54


Other references

Breart, G., 1989: Classification and definition of hypertension in pregnancy. La Revue du Praticien 39(12): 1055-1056

Hinds, M.W.; Cohen, H.I.; Kolonel, L.N., 1982: Tuberculosis and lung cancer risk in nonsmoking women. Prior pulmonary tuberculosis infection was studied in 211 non-Caucasian female lung cancer patients and 419 sex, race, age, smoking history and birthplace-matched control subjects by searching the Hawaii State Tuberculosis Branch patient records....

Porter W.R.; Neal R.A., 1978: Studies of the in vitro metabolism of thio acetamide and thio acetamide sulfine. Toxicology & Applied Pharmacology 45(1): 225

Robinson, D.; Monkman, J., 1998: Innovation in practice at Walsgrave Hospital. Nursing Standard 12(11): 34-35

Rosenzweig, B.; Pinthus, J.H.; Kleinmann, N.; Joffe, E.; Erlich, T.; Fridman, E.; Winkler, H.; Mor, Y.; Ramon, J.; Dotan, Z.A., 2015: The relative contribution of urine extravasation to elevate plasma creatinine levels in acute unilateral ureteral obstruction. Rising levels of plasma creatinine in the setting of acute unilateral ureteral obstruction (AUUO) often reflects acute renal failure, mandating kidney drainage. We hypothesize that re-absorption of peri-renal urine extravasation (PUE), a common re...

Uki, N.; Kikuchi, S., 1984: Regulation of maturation and spawning of an abalone, Haliotis Gastropoda by external environmental factors. Temperature appears to be the major external environmental factor which regulates the breeding cycle of this mollusc, because the artificially produced spawning period (after 1500 degree-days) corresponds well with the natural breeding season in t...

Parker, G.A.; Simmons, L.W., 1989: Nuptial feeding in insects theoretical models of male and female interests. The authors present a series of prospective models of nuptial feeding, mainly for insects. The models examine various optimal male and female strategies, but do not include any element of mate choice in which the female chooses males in relation t...

Bayon, F.; Ayrault, J.P.; Pichon, P., 1982: Barley yellow dwarf. A review is presented of investigations in France on barley yellow dwarf in cereals, including the role and control of aphid vectors, especially Rhopalosiphum padi (L.), Metopolophium dirhodum (Wlk.) and Sitobion avenae (F.).

Thenappan, T.; Anderson, A.S.; Jeevanadham, V.; Rich, J.D.; Shah, A.P., 2013: Treatment of left ventricular assist device thrombosis with extended catheter-directed intraventricular thrombolytic therapy. Circulation. Heart Failure 6(3): E27-E29

Beamer, L.J.; Carroll, S.F.; Eisenberg, D., 1998: The BPI/LBP family of proteins: a structural analysis of conserved regions. Two related mammalian proteins, bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP), share high-affinity binding to lipopolysaccharide (LPS), a glycolipid found in the outer membrane of Gram-negative bac...