+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Sweets for a bitter end: lung cancer cell-surface protein glycosylation mediates metastatic colonization

, : Sweets for a bitter end: lung cancer cell-surface protein glycosylation mediates metastatic colonization. Cancer Discovery 5(2): 109-111

Glycosylation is one of the most predominant forms of cell-surface protein modifications, yet its deregulation in cancer and contribution to tumor microenvironment interactions remain poorly understood. In this issue of Cancer Discovery, Reticker-Flynn and Bhatia characterize an enzymatic switch in lung cancer cells that triggers aberrant surface protein glycosylation patterns, adhesion to lectins on the surface of inflammatory cells, and subsequent metastatic colonization of the liver.


PMID: 25656895

DOI: 10.1158/2159-8290.CD-15-0013

Other references

Zhang, P.; Chu, H.; Li, X.; Feng, W.; Deng, P.; Yuan, L.; Gong, B., 2010: Alternative strategy for adjusting the association specificity of hydrogen-bonded duplexes. A strategy for creating new association specificity of hydrogen-bonded duplexes by varying the spacings between neighboring hydrogen bonds is described. Incorporation of naphthalene-based residues has provided oligoamide strands that pair into dup...

Graham, R.M.; Owens, W.A., 1999: Pathogenesis of inherited forms of dilated cardiomyopathy. New England Journal of Medicine 341(23): 1759-1762

Spoon, W., 1940: Quality description of derris powder. Changes in the rules for standardizing derris powder are given, chief of which are: new prescriptions for the size of the powder, the number of mesh allowed. A prescription is given for the ash content, which may amt. to max. 8% of the air-dried p...

Parrillo, J.E., 2004: Abnormal ECG in man admitted to ICU with chest pain and irregular pulse. Chest 125(2): 775-776

Swaen, G.J.; Vossenaar, T.; Wyers, H.J., 1964: Abnormal Mitosis In Gliomas. An abnormal kind of mitosis is described in gliomas. It occurred in large glial cells and is characterized by greatly contracted chromosomes which sometimes partly fused into fairly large granules. These granules are spread on the surface of an im...

Kang, I.Gyu.; Jung, J.Hyun.; Kim, S.Tae.; Kim, Y.Jin., 2014: Reconstruction of a columellar defect with a nasolabial island flap. Columellar skin defects may be caused by excision of cutaneous malignancy, trauma, or tissue necrosis associated with surgery. Although columellar skin necrosis rarely occurs following rhinoplasty, this condition might be more common when using an...

Boyce, W.H., 1963: Physico-chemical characteristics of matrix substance A as recovered from the urine and matrix of patients with urinary calculi. Ann Internal Med 58(4): 741

Pfeifle, C.E.; Rubinstein, S.M., 1996: Synopsis of the standard 'Low back pain' by the Dutch Society of Family Physicians. Nederlands Tijdschrift Voor Geneeskunde 140(35): 1780-1781

Meshcheryakov R.P.; Stolbov Y.M., 1968: Measurement of the isotopic composition of calcium in natural materials. English translation of Russian article (see this Bibliography Vol. 32, No. 12, 05 E68-16979).

Shoemaker, W.C., 1971: Sequential hemodynamic patterns in various causes of shock. Surgery, Gynecology & Obstetrics 132(3): 411-423