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Systemic and cell-specific mechanisms of vasculopathy induced by human immunodeficiency virus and highly active antiretroviral therapy


, : Systemic and cell-specific mechanisms of vasculopathy induced by human immunodeficiency virus and highly active antiretroviral therapy. Journal of Vascular Surgery (): -

Patients infected with human immunodeficiency virus (HIV) have higher rates of dyslipidemia, atherosclerosis, and chronic inflammation that can damage the vascular system compared with the general population. This can be attributed both to HIV itself and to highly active antiretroviral therapy (HAART) they receive. This review outlines the mechanisms by which HIV and HIV medications can cause vascular complications and identifies strategic areas of research to treat these dysfunctions. HIV and HAART affect the vascular system through several mechanisms that target systemic or metabolic systems and specific cells. HIV causes dyslipidemia and chronic immune activation, which can contribute to atherosclerosis. In addition, HIV damages macrophages, endothelial cells, smooth muscle cells, and platelets, and this damage also plays a role in the development of atherosclerosis. HAART, particularly protease inhibitors, interferes with cholesterol metabolism and can affect macrophages, endothelial cells, and smooth muscle cells. The metabolic changes and cell damage induced by HIV and HAART put HIV patients at increased risk for atherosclerosis, dyslipidemia, and serious cardiovascular events such as myocardial infarction and stroke. HIV patients have increased risk of developing potentially life-threatening cardiovascular pathology, which cannot be explained by traditional cardiovascular risk factors alone. More research is needed into therapies to target this HIV-specific vasculopathy.

US$19.90

PMID: 26994951

DOI: 10.1016/j.jvs.2016.01.036


Other references

Stárka, L.; Pospísilová, H.; Hill, M., 2009: Free testosterone and free dihydrotestosterone throughout the life span of men. The dihydrotestosterone/testosterone ratio seems to be an important factor in the expression of androgenic activity, especially in the prostate and pilosebaceous unit. Whereas the decline of testosterone in aging men is well known, controversial d...

Hu, H-Tang.; Hsueh, Y-Ping., 2015: Calcium influx and postsynaptic proteins coordinate the dendritic filopodium-spine transition. Dendritic spines are the major locations of excitatory synapses in the mammalian central nervous system. The transformation from dendritic filopodia to dendritic spines has been recognized as one type of spinogenesis. For instance, syndecan-2 (SDC...

Jones, N.A.; Nepogodiev, S.A.; Field, R.A., 2005: Efficient synthesis of methyl lycotetraoside, the tetrasaccharide constituent of the tomato defence glycoalkaloid alpha-tomatine. Branched oligosaccharide lycotetraose, beta-D-glucopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranose, is a key constituent of many steroidal saponins, including glycoalkaloid alpha-tomat...

Gunawardana, V.E., 1977: Stages of spermatids in the domestic fowl: a light microscope study using Araldite sections. Ten stages of spermatid maturation were recognized. State 1 spermatids showed the idiosome containing the proacrosome in the vicinity of the nucleus. Stage 2 showed the idiosome to be in contact with the nuclear membrane. In stages 3 and 4, the pr...

Kobayashi, Y.; Tsukamoto, T.; Miyai, N.; Nakanishi, Y., 2004: Anthracnose of three-leaf akebia (Akebia trifoliata Koidzumi) caused by Colletotrichum acutatum. In October 2001, anthracnose caused by Colletotrichum acutatum Simmonds ex Simmonds was found on three-leaf akebia (Akebia trifoliata) in Saitama, Japan. This is the first report of anthracnose on three-leaf akebia caused by C. acutatum.

Doidge, E.M., 1932: A wilt disease of cucurbits. Report of a wilt of cucurbits in S. Africa[long dash]shown experimentally to be due to Fusarium javanicum var. theobromae [long dash]apparently the 1st report for these host plants.

Hamilton, A.E.Ricardo.; Westwood, D.A.; Cuda, T.J.; Stevenson, A.R.L., 2017: Identification of the ureter during robotic colorectal surgery using lighted stents - a video vignette. The incidence of ureteric injury during colorectal surgery is reported to be 0.28-7.6% [1,2]. Although there is no evidence that ureteric stents reduce the incidence of injury, they may assist early intraoperative identification of injury and thus...

Brewer, G.J.; Reichensperger, J.D.; Brinton, R.D., 2005: Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons. To determine the impact of aging and 17 beta-estradiol on neuronal Ca2+ homeostasis, intracellular Fura-2 Ca2+-imaging was conducted during, 20-pulses of glutamate in hippocampal neurons Cultured front embryonic (E18). middle-age (10 months) and o...

Laffey, J., 2011: Placebo blocks in local anaesthesia studies: the need for balance. Anaesthesia 66(5): 390-2; Author Reply 392-3

Lucas, J., 1790: Observations on Stone in the Urinary Bladder, and on Lithotomy. London Medical Journal 11(Pt 3): 237-255