+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

TLR signaling-induced CD103-expressing cells protect against intestinal inflammation

, : TLR signaling-induced CD103-expressing cells protect against intestinal inflammation. Inflammatory Bowel Diseases 21(3): 507-519

Toll-like receptor (TLR) expression in patients with inflammatory bowel disease is increased when compared with healthy controls. However, the impact of TLR signaling during inflammatory bowel disease is not fully understood. In this study, we used a murine model of acute phase inflammation in bone marrow chimeric mice to investigate in which cell type TLR2/4 signal induction is important in preventing intestinal inflammation and how intestinal dendritic cells are influenced. Mice were either fed with wild-type bacteria, able to initiate the TLR2/4 signaling cascade, or with mutant strains with impaired signal induction capacity. The induction of the TLR2/4 signal cascade in epithelial cells resulted in inflammation in bone marrow chimeric mice, whereas induction in hematopoietic cells had an opposed function. Furthermore, feeding of wild-type bacteria prevented disease; however, differing signal induction of bacteria had no effect on lamina propria dendritic cell activation. In contrast, functional TLR2/4 signals resulted in increased frequencies of CD103-expressing lamina propria and mesenteric lymph node dendritic cells, which were able to ameliorate disease. The TLR-mediated amelioration of disease, the increase in CD103-expressing cells, and the beneficial function of TLR signal induction in hematopoietic cells indicate that the increased expression of TLRs in patients with inflammatory bowel disease might result in counterregulation of the host and serve in preventing disease.


PMID: 25647153

DOI: 10.1097/MIB.0000000000000292

Other references

Degginger, Kathe, 1964: Vegetables that eat meat. Natl Wildl 2(4): 8-9

Yang, M.Y.; Fortune, J.E., 2008: The capacity of primordial follicles in fetal bovine ovaries to initiate growth in vitro develops during mid-gestation and is associated with meiotic arrest of oocytes. In cattle and other species in which the pool of resting, primordial follicles is formed during fetal life, little is known about the regulation of the early stages of ovarian follicular development. We used histological morphometry and a combinat...

Kazafeos, K., 2012: Incretin effect: GLP-1, GIP, DPP4. The term incretin effect was used to describe the fact that oral glucose load produces a greater insulin response than that of an isoglycemic intravenous glucose infusion. This difference has been attributed to gastrointestinal peptides GLP-1 and...

Arroyave, G., 1995: Agricultural and food policies. Some concerns regarding their nutritional relevance. In recent times, nutrition analysts have been emphasizing the fact that the most critical nutritional unfulfilled need in underdeveloped countries is energy or quantity of food. This has prompted some leading food economist and agricultural policy...

Dempster, W.F.; Van Thillo, M.; Alling, A.; Allen, J.P.; Silverstone, S.; Nelson, M., 2005: Technical review of the Laboratory Biosphere closed ecological system facility. Laboratory Biosphere is a 40 m3 closed life system that commenced operation in May 2002. Light is from 12,000 W of high pressure sodium lamps over planting beds with 5.37 m2 of soil. Water is 100% recycled by collecting condensate from the tempera...

Ross, G.D.; Hansen, R.D.; Allendorf, D.J.; Baran, J.T.; Yan, J.; Subbarao, K.; Haribabu, B.; Lambris, J.D., 2003: Tumor regression mediated by beta-glucans against iC3b-opsonized tumors requires CR3+ neutrophils recruited via C5a and leukotriene B4. FASEB Journal 17(7): C128, April 14

Anonymous, 1984: Preparation, characterization and storage of human ferritin for use as a standard for the assay of serum ferritin. International Committee for Standardization in Haematology (Expert Panel on Iron). This paper describes studies on the source, preparation, characterization and storage of human ferritin for use as a standard for the immunoassay of serum ferritin. Ferritin was prepared from the liver or spleen by methods including either ultrace...

Fraticelli, P.; Gabrielli, B.; Pomponio, G.; Valentini, G.; Bosello, S.; Riboldi, P.; Gerosa, M.; Faggioli, P.; Giacomelli, R.; Del Papa, N.; Gerli, R.; Lunardi, C.; Bombardieri, S.; Malorni, W.; Corvetta, A.; Moroncini, G.; Gabrielli, A.; Giammarioli, A.Maria.; Cuomo, G.; Iudici, M.; Bartoloni, E.; Cipriani, P.; Gabbriellini, L.; Svegliati, S.; Amico, D.; Marcosignori, M.; Bonifazi, M.; Giori, S., 2015: Low-dose oral imatinib in the treatment of systemic sclerosis interstitial lung disease unresponsive to cyclophosphamide: a phase II pilot study. Pulmonary involvement represents a major cause of death of systemic sclerosis (SSc) patients. Recent data suggest that tyrosine kinase inhibitors, such as imatinib, may be a therapeutic option for SSc patients. However, preliminary published clini...

Decamps, H., 1968: Vicariances ecologiques chez les Trichopteres des Pyrenees. Annales de Limnologie, 4: 1-50

Harms, J.E.; Benveniste, M.; Kessler, M.; Stone, L.M.; Arai, A.C.; Partin, K.M., 2014: A charge-inverting mutation in the "linker" region of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors alters agonist binding and gating kinetics independently of allosteric modulators. AMPA receptors are gated through binding of glutamate to a solvent-accessible ligand-binding domain. Upon glutamate binding, these receptors undergo a series of conformational rearrangements regulating channel function. Allosteric modulators can b...