+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The Consumption of Synbiotic Bread Containing Lactobacillus sporogenes and Inulin Affects Nitric Oxide and Malondialdehyde in Patients with Type 2 Diabetes Mellitus: Randomized, Double-Blind, Placebo-Controlled Trial

, : The Consumption of Synbiotic Bread Containing Lactobacillus sporogenes and Inulin Affects Nitric Oxide and Malondialdehyde in Patients with Type 2 Diabetes Mellitus: Randomized, Double-Blind, Placebo-Controlled Trial. Journal of the American College of Nutrition 35(6): 506-513

To our knowledge, no reports are available indicating the effects of synbiotic bread consumption on nitric oxide (NO), biomarkers of oxidative stress, and liver enzymes among patients with type 2 diabetes mellitus (T2DM). This study was performed to determine the effects of the daily consumption of synbiotic bread on NO, biomarkers of oxidative stress, and liver enzymes in patients with T2DM. This randomized, double-blind, placebo-controlled trial was performed among 81 patients with diabetes, aged 35-70 years old. After a 2-week run-in period, patients were randomly divided into 3 groups: group A (n = 27) received synbiotic bread containing viable and the heat-resistant probiotic Lactobacillus sporogenes (1 × 108 CFU) and 0.07 g inulin per 1 g, group B (n = 27) received probiotic bread containing Lactobacillus sporogenes (1 × 108 CFU), and group C (n = 27) received control bread for 8 weeks. Patients were asked to consume the synbiotic, probiotic, or control breads 3 times a day in 40 g packages for a total of 120 g/day. Fasting blood samples were taken at baseline and after an 8-week intervention for quantificationof related markers. After 8 weeks, the consumption of synbiotic bread compared to the probiotic and control breads resulted in a significant rise in plasma NO (40.6 ± 34.4 vs 18.5 ± 36.2 and -0.8 ± 24.5 µmol/L, respectively, p < 0.001) and a significant reduction in malondialdehyde (MDA) levels (-0.7 ± 0.7 vs 0.6 ± 1.7 and 0.5 ± 1.5 µmol/L, respectively, p = 0.001). We did not find any significant effect of the synbiotic bread consumption on plasma total antioxidant capacity (TAC), plasma glutathione (GSH), catalase, serum liver enzymes, calcium, iron, magnesium levels, and blood pressure compared to the probiotic and control breads. In conclusion, consumption of the synbiotic bread for 8 weeks among patients with T2DM had beneficial effects on plasma NO and MDA levels; however, it did not affect plasma TAC, GSH, catalase levels, serum liver enzymes, calcium, iron, magnesium levels, and blood pressure.


PMID: 26430929

DOI: 10.1080/07315724.2015.1032443

Other references

Birney, D.G.; Blake, W.E.; Meldrum, P.R.; Peach, M.E., 1968: Adsorption of chloro-complexes of the first row transition elements by Dowex A-1. A study has been made of the adsorption of chlorocomplexes of the first row transition metals by the chelating resin Dowex A-1, and possible mechanisms for adsorption have been reviewed. Relative adsorption follows the series Zn(II) > Co(II) =...

Britton, D.M.; Brunton, D.F., 1992: Isoetes x jeffreyi hyb.nov. a new isoetes isoetes macrospora x isoetes riparia from quebec canada. A new interspecific hybrid in Isoetes, Isoetes macrospora Dur. .times. riparia Engelm., is delineated and described Papineau County, Quebec, Canada by means of cytology and scanning electron microscopy of spores. Isoetes .times. jeffreyi D.M. Brit...

Rahmani A.R., 1981: Large racket tailed drongo dicrurus paradiseus and common babbler turdoides caudatus. Journal of the Bombay Natural History Society 78(2): 380

Ivanov, V.B., 1986: Characteristics of the organization of cell proliferation in plants in relation to the problem of stem cells. Cellular patterns of continual cell proliferation are considered in plants and animals. In plants, the cells, analogous to the animal stem cells, can be formed many times during plant ontogenesis. Their functioning as stem cells is determined by t...

Cash, C.D.; Vayer, P.; Mandel, P.; Maitre, M., 1985: Tryptophan 5 hydroxylase ec rapid purification from whole rat brain and production of a specific antiserum. Tryptophan 5-hydroxylase (EC; L-tryptophan tetrahydropteridine:oxygen oxidoreductase) was purified to electrophoretic homogeneity from whole brain supernatant using the following steps: pteridine-agarose affinity chromatography, hydropho...

Chung, K.C., 2000: Successful replantation of a completely avulsed scalp. Annals of Plastic Surgery 44(2): 233-234

Scarborough, Robert M., 1998: Eptifibatide Platelet antiaggregatory glycoprotein IIb/IIIa antagonist fibrinogen receptor antagonist. Drugs of the Future 23(6): 585-590, June

Singh Baldeo; Emery Nelson, 2002: Fracture-gradient predictions in depleted sands in the Gulf Coast sedimentary basin. The primary objective of this work was to estimate fracture gradients in depleted sands. This information is necessary in predicting lost-circulation zones and optimizing drilling plans. Large reserves are known to exist in deeper horizons underne...

Bergogne-Berezin, E., 1995: New concepts in the pulmonary disposition of antibiotics. Despite interpretive problems associated with studies of antibiotic concentrations in tissues, it is of major interest to correlate the presence of the drug at significant concentrations in lung tissues and fluids at a particular site with its cli...

Soto, C.M.; Kleinman, K.P.; Simon, S.R., 2002: Quality and correlates of medical record documentation in the ambulatory care setting. Documentation in the medical record facilitates the diagnosis and treatment of patients. Few studies have assessed the quality of outpatient medical record documentation, and to the authors' knowledge, none has conclusively determined the cor...