+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The Potential Role of Nucleic Acids in Mediating Autoimmune Recognition Events: The Alpha-Omega of Innate Immunity

, : The Potential Role of Nucleic Acids in Mediating Autoimmune Recognition Events: The Alpha-Omega of Innate Immunity. Journal of Interferon & Cytokine Research 34(12): 958-962

The hypothesis proposed in this article suggests that in the innate immune response involving IgM moieties, nucleic acids and probably miRNAs play roles as mediators and regulators. After a discussion on how such a mechanism may operate, various diagnostic and therapeutic possibilities will be suggested.


PMID: 25493964

DOI: 10.1089/jir.2014.0016

Other references

Norlund L.; Lindstrom P.; Sehlin J., 1984: Glibenclamide increases the osmotic resistance of beta cells by affecting potassium mediated volume regulatory mechanisms. Diabetologia 27(2): 315A

Heidrich, O.; Reckien, D.; Olazabal, M.; Foley, A.; Salvia, M.; de Gregorio Hurtado, S.; Orru, H.; Flacke, J.; Geneletti, D.; Pietrapertosa, F.; Hamann, J.J-P.; Tiwary, A.; Feliu, E.; Dawson, R.J., 2016: National climate policies across Europe and their impacts on cities strategies. Globally, efforts are underway to reduce anthropogenic greenhouse gas emissions and to adapt to climate change impacts at the local level. However, there is a poor understanding of the relationship between city strategies on climate change mitigat...

Cromheecke, M.; Vermeij, J.; Grond, A.J.ris, K.; Konings, A., W.T.; Oldhoff, J.; Hoesktra, H., J., 1993: Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT). Purpose: The purpose of the study is to obtain dose guidelines for the deliver, of intraoperative radiotherapy to the liver of patients with colorectal liver metastases. Following partial resection of the liver, a single high dose of 10, 20, 25, a...

Wong, H-Lok.; Siu, W-Sum.; Fung, C-Hei.; Zhang, C.; Shum, W-Ting.; Zhou, X-Lin.; Lau, C.Bik-San.; Zhang, J-Fang.; Leung, P-Chung.; Fu, W-Ming.; Ko, C-Hay., 2015: Characteristics of stem cells derived from rat fascia: in vitro proliferative and multilineage potential assessment. Fascia‑derived stem cells (FDSCs) were previously isolated from the fascia of the gluteus maximus of the rat. However, the use of FDSCs as a cell source for musculoskeletal tissue engineering has not been compared with that of adipose‑derived...

Dixon, D.L.; Breeding, L.C.; Ekstrand, K.G., 1992: Linear dimensional variability of three denture base resins after processing and in water storage. It has been shown that denture base resins shrink during curing and expand during storage in water. This investigation measured and compared linear dimensional changes of three denture base resins that occurred during processing and after storage...

Inoue, A.; Tobe, K.; Suzuki, R.; Aoyama, M.; Kowatari, N.; Yoshimatsu, H.; Kato, H.; Kadowaki, T., 2003: Beta3-Adrenoceptor agonist treatment ameliorated leptin resistance in Irs2-/- mice. Diabetes 52(Supplement 1): A388

CABAK.V.; GRESHAM.G.A.; McCANCE.R.A., 1962: Severe undernutrition in growing and adult animals. 10. The skin and hair of pigs. During development the density of the hair and apocrine glands falls, and the hairs become longer, thicker and heavier. Undernutrition, by preventing growth, prevented normal expansion of the surface area and maintained a high hair and gland count...

Fenn, N.J.; Johnson, R.C.; Maw, A.; Sharma, B.; Almeida, W.; Horgan, K.; Webster, D.J.T.; Hughes, L.E.; Mumford, M.; Shandall, A.A.; Mansel, R.E., 1994: Local recurrence after mastectomy and immediate reconstruction for carcinoma of the breast. Breast Cancer Research & Treatment 32(SUPPL ): 70

Glukhikh, L.S., 1973: Calculation of internal shrinkage stresses in the glue-line. Presents an analytical expression of the static internal stresses caused by glue-line shrinkage in the different elements of the wood/glue/wood system.

Zhai, X.; Zhang, C.; Zhao, G.; Stoll, S.; Ren, F.; Leng, X., 2017: Antioxidant capacities of the selenium nanoparticles stabilized by chitosan. Selenium (Se) as one of the essential trace elements for human plays an important role in the oxidation reduction system. But the high toxicity of Se limits its application. In this case, the element Se with zero oxidation state (Se<sup>0<...