geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin


, : The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin. Food and Chemical Toxicology 81: 160-170

Phenolic compounds not only contribute to the sensory qualities of fruits and vegetables but also exhibit several health protective properties. Limonene and naringin are the most popular phenolics found in Citrus plants. In this study, we investigated the antioxidant capacities of limonene and naringin by the trolox equivalent antioxidant capacity (TEAC) assay and the cytotoxic effects by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in Chinese hamster fibroblast (V79) cells. The genotoxic potentials of limonene and naringin were evaluated by micronucleus (MN) and alkaline COMET assays in human lymphocytes and V79 cells. Limonene and naringin, were found to have antioxidant activities at concentrations of 2-2000 µM and 5-2000 µM respectively. IC50 values of limonene and naringin were found to be 1265 µM and 9026 µM, respectively. Limonene at the concentrations below 10,000 µM and naringin at the all concentrations studied, have not exerted genotoxic effects in lymphocytes and in V79 cells. Limonene and naringin at all concentrations revealed a reduction in the frequency of MN and DNA damage induced by H2O2.

US$19.90

PMID: 25896273

DOI: 10.1016/j.fct.2015.04.015


Other references

Sheikh M.I.; Moller J.V., 1970: The kinetic parameters of renal transport of para amino hippurate in vitro. Biochimica et Biophysica Acta 196(2): 305-319

Borba, E.-Leite; Semir, J., 1999: Temporal variation in pollinarium size after its removal in species of Bulbophyllum: A different mechanism preventing self-pollination in Orchidaceae. In Bulbophyllum involutum and B. ipanemense (Orchidaceae), two closely related species, shortly after removal the pollinarium has a diameter of approximately twice that of the entrance of the stigmatic cavity, requiring a mean time of 105 to 135 m...

Ashurmetov A.A., 1982: Structure and development of anthers micro sporogenesis and pollen formation in meristotropis bucharica. Uzbekskii Biologicheskii Zhurnal (3): 35-38

DiMaio, D.; Miller, G., 2007: Thirty years into the genomics era: tumor viruses led the way. Yale Journal of Biology and Medicine 79(3-4): 179-185

Fichtel, L., 1977: Gruppentauchfahrt nach Giens/Toulon. Delphin, 2411: 36-38

Vasquez Astrid P.; Regens James L.; Gunter James T., 2004: Environmental persistence of 2,3,7,8-tetrachlorodibenzo-p-dioxin in soil around Hardstand 7 at Eglin Air Force Base, Florida. Background and Goal. A number of global events have generated intense scientific scrutiny and public concern of polychlorinated dibenzo-p-dioxins (dioxin). Dioxins have been associated with a range of adverse health effects. 2,3,7,8-tetrachlorodib...

Honer, C., 1993: California quality. Safeway Inc.'s liquid milk plant, San Leandro, California, USA, receives approx. 10 million lb milk/wk, 45% of which is transported directly from independent milk producers. The plant produces liquid milk, chocolate milk, buttermilk, fruit ju...

Bretos, Iñigo.; Jiménez, R.; Ricote, Jús.; Calzada, M.Lourdes., 2017: Low-temperature crystallization of solution-derived metal oxide thin films assisted by chemical processes. Over the last few years the efforts devoted to the research on low-temperature processing of metal oxide thin films have increased notably. This has enabled the direct integration of metal oxide layers (amorphous semiconductors) on low-melting-poi...

Merle M.; Lefevre G.; Milhaud G., 1979: Predicted secondary structure of calcium in relation to the biological activity. The secondary structure of the natural analogs of calcitonin [human, rat, pig, cow, sheep, salmon I, II and III and eel calcitonin] were predicted using the methods of Burgess et al., Chou and Fasman, and Lim. The predicted structures were similar...

Shulman, R., 1967: Psychiatric aspects of pernicious anaemia: a prospective controlled investigation. The psychiatric status of 27 patients with pernicious anaemia and 21 control anaemic patients was examined. Psychiatric symptoms included depression, anxiety, loss of libido, irritability, poor concentration and impaired memory. Symptoms, mild in...