geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The antioxidative property of melatonin against brain ischemia


, : The antioxidative property of melatonin against brain ischemia. Expert Review of Neurotherapeutics 16(7): 841-848

This review briefly summarizes some of the large amount of data documenting the ability of melatonin to limit molecular and organ tissue damage in neural ischemia-reperfusion injury (stroke), where free radicals are generally considered as being responsible for much of the resulting tissue destruction. Melatonin actions that have been identified include its ability to directly neutralize a number of toxic reactants and stimulate antioxidative enzymes. Furthermore, several of its metabolites such as N(1)-acetyl-N(2)-formyl-5- methoxykynuramine (AFMK) and N(1)-acetyl-5-methoxykynuramine (AMF), are themselves scavengers suggesting that there is a cascade of reactions that greatly increase the efficacy of melatonin. Expert Commentary: However, the mechanisms by which melatonin is protective in such widely diverse areas of the cell and different organs are likely not yet all identified.

US$19.90

PMID: 27108742

DOI: 10.1080/14737175.2016.1182020


Other references

Kondrat'eva, I.N., 1968: Reactions of visual cortex neurons to light of increasing intensity. Zhurnal Vysshei Nervnoi Deiatelnosti Imeni i P Pavlova 18(1): 157-159

Meelhuysen, F.E.; Halpern, D.; Quast, J., 1968: Treatment of flexor spasticity of hip by paravertebral lumbar spinal nerve block. Archives of Physical Medicine and Rehabilitation 49(12): 717-722

Tsotsur V.S.; Baryshnikov V.I.; Mukhamedzyanova A.S.; Vezhnin S.A., 1982: Recognition of landscape anomalies with remote sensing methods in the western regions of the Blagoveshchensk Basin. Neftegazovaya Geologiya i Geofizika 1982(9): 10

Bottura, C.; Coutinho, V., 1971: Chromosomes and leukemia. II: Acute leukemia. Revista Paulista de Medicina 78(1): 5-10

Walters, J.K., 1987: Comment: pharmacokinetic comparison of clindamycin dosing. Drug Intelligence & Clinical Pharmacy 21(7-8): 661-662

Enright Richard C.; Isphording Wayne C.; Lodding William, 1969: Paleoenvironment and diagenesis in marginal marine sediments of the New Jersey Tertiary. Abstracts with Programs Geological Society of America: 7; Pages 57. 1969.

Carella, A.; Andreula, C., 1994: Diagnostic imaging of HIV-related intracranial non expansive lesions and myelopathies. Rays 19(1): 68-86

Leger, L.; Marcenac, L.; D.F.Rron, A.; Bitry, B.Ely, C.; Guyet, P.; Poulet, L., 1958: Use of woven artificial fiber vascular prosthesis. La Presse Medicale 66(6): 128-130

Anonymous, 1929: John Owen, M.D., F.R.C.P. British Medical Journal 1(3553): 272-273

Seymenoğlu, Göktuğ.; Başer, E.; Tansuğ, N.; Demireli, P., 2013: An unusual association of Goldenhar syndrome. Goldenhar syndrome is well known for its classical triad of epibulbar dermoids or lipodermoids, auricular appendages and pretragal fistulas. Here we report a case of Goldenhar syndrome with an unusual association of a fibroepithelial polyp attache...