+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The influence of sighing respirations on infant lung function measured using multiple breath washout gas mixing techniques

, : The influence of sighing respirations on infant lung function measured using multiple breath washout gas mixing techniques. Physiological Reports 3(4): -

There is substantial interest in studying lung function in infants, to better understand the early life origins of chronic lung diseases such as asthma. Multiple breath washout (MBW) is a technique for measuring lung function that has been adapted for use in infants. Respiratory sighs occur frequently in young infants during natural sleep, and in accordance with current MBW guidelines, result in exclusion of data from a substantial proportion of testing cycles. We assessed how sighs during MBW influenced the measurements obtained using data from 767 tests conducted on 246 infants (50% male; mean age 43 days) as part of a large cohort study. Sighs occurred in 119 (15%) tests. Sighs during the main part of the wash-in phase (before the last 5 breaths) were not associated with differences in standard MBW measurements compared with tests without sighs. In contrast, sighs that occurred during the washout were associated with a small but discernible increase in magnitude and variability. For example, the mean lung clearance index increased by 0.36 (95% CI: 0.11-0.62) and variance increased by a multiplicative factor of 2 (95% CI: 1.6-2.5). The results suggest it is reasonable to include MBW data from testing cycles where a sigh occurs during the wash-in phase, but not during washout, of MBW. By recovering data that would otherwise have been excluded, we estimate a boost of about 10% to the final number of acceptable tests and 6% to the number of individuals successfully tested.


PMID: 25847916

DOI: 10.14814/phy2.12347

Other references

Brady, T.J.; Thrall, J.H.; Clare, J.M.; Rogers, W.L.; Lo, K.; Pitt, B., 1979: Exercise radionuclide ventriculography: practical considerations and sensitivity of coronary artery disease detection. Eighty-nine patients were evaluated for coronary artery disease (CAD) with exercise radionuclide ventriculography (ERV) and contrast coronary angiography. In 70 patients with documented lesions the ERV was abnormal in 65 for a sensitivity of 93%....

Jacobs, D.K.; Gates, R.D., 2001: Is reproductive signaling antecedent to metazoan sensory and neural organization?. We explored the POU/Homeodomain containing developmental genes down the tree of life, recovering bilaterian, cnidarians, ctenophore and sponges sequence. The genes in question include a sense organ specific gene - Brain3, a pituitary specific gene...

Saito, Y., 1998: Is cholesteryl ester transfer protein (CETP) deficiency atherogenic in familial hypercholesterolemia. Internal Medicine 37(6): 495-496

Nordic-Adhesion-Prevention-Study-Group, 1995: The efficacy of Interceed (TC7) for prevention of reformation of postoperative adhesions on ovaries, fallopian tubes, and fimbriae in microsurgical operations for fertility: A multicenter study. Objective: To evaluate the efficacy of Interceed as an adjuvant in the prevention of postoperative adhesion reformation to the ovary, fallopian tube, and fimbria when used together with microsurgical techniques. Design: Prospective, randomized, mu...

L'vov, G.S.; Maslovskaya, R.V., 1961: Quantitative shifts in the erythrocytes and leukocytes under the effect of emotions related to surgical operations. An increase in the number of erythrocytes (by an average of 375,000 cells/mm3) and leukocytes (by 49%) was noted in the majority of patients at the time they were placed on the operating table. During experimental hyperadrenalinemia (subcutaneous...

Bybee Karen, 2003: Maximizing reserves growth and profitability in tight gas sands. An alternative tight gas-sand reservoir development strategy allows operators to maximize gas recovery and net present value while minimizing capital expenditures. The strategy uses a "parallel" development technique, allowing an operato...

Maksimcuk, I.H., 1956: Development of new forms and characters in millet on hybridization.. Forms with two grains per spikelet have appeared in a number of crosses and since the character is recessive it can be fixed by selection and be introduced into other forms by hybridization. Such forms have appeared particularly frequently in cros...

Mironenko Y.T., 1968: Skin galvanic reflex during the study of taste by inst electric current human. Fiziologicheskii Zhurnal SSSR Imeni I M Sechenova 54(10): 1160-1162

Gercel C.; Schroder E.W., 1984: Relationship between cell surface glycoconjugates and cell cell interactions of murine and human melanoma. Journal of Cell Biology 99(4 PART 2): 66A

Morse, Ed., 1867: Ed. MORSE, who some years ago went so far as to distinguish several tribes and numerous genera withi. Ed. MORSE, who some years ago went so far as to distinguish several tribes and numerous genera within the genus Helix as defined by Lamarck and Pfeiffer, returns now, in a popular treatise, to the system of these authors, regarding even the Hyalin...