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The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking

, : The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking. Biochemical and Biophysical Research Communications (): -

NlmCategory="UNASSIGNED">Neuronal growth regulator 1 (NEGR1) is a newly identified raft-associated protein, which has recently been spotlighted as a new locus related to human obesity. Niemann-Pick disease Type C2 (NPC2) protein functions as a key player in the intracellular cholesterol trafficking, and its defect is linked to a fatal human neurodegenerative disease, NPC. In this study, we identified that NEGR1 interacts with NPC2 and increases its protein stability. Ectopically expressed NEGR1 proteins relieved an abnormal cholesterol accumulation in endosomal compartments. Importantly, NEGR1-defective mouse embryonic fibroblast cells exhibit increased cholesterol levels and triglyceride contents. These findings provide the first insight into the role of NEGR1 in intracellular cholesterol homeostasis, possibly explaining the missing link between NEGR1 with human obesity.


PMID: 27940359

DOI: 10.1016/j.bbrc.2016.12.043

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Anonymous, 2016: Assessment Skills for Paramedics (Second edition) Blaber Amanda Y and Harris Graham (Eds) Assessment Skills for Paramedics (Second edition) 336pp £26.99 Open University Press 9780335262168 0335262163 [Formula: see text. Despite its title, this book has content that can be applied to many areas of clinical practice. The evidence-based text provides a logical approach to learning as well as undertaking a physiological patient assessment. With lots of helpful illust...

Aleev, M.Yu, 1992: Active metabolism in flagellated planktonic algae. The active metabolism (Q) in 19 species (Nephrochloris salina, Carteria sp., Exuviaella pusilla, E. cordata, Platymonas viridis, Dunaliella salina, D. tertiolecta, D. maritima, Amphidinium klebsi, Peridinium triquetrum, P. trochoideum, Gymnodinium...

Zeeman B.J.V.R.; Mitchell G.M.; Olazabal A.E.; Collopy P.A.; Morrison W.A.; O'brien B.M., 1988: The significance of resection length on the patency rate and the histopathology of experimentally avulsed and microsurgically repaired blood vessels. The significance of resection length on patency rate, and the histopathology, of microsurgically repaired avulsed blood vessels was examined at 3 weeks in two groups of experimentally avulsed rabbit femoral arteries repaired by different surgeons...

Lai, P.K.; Wang, Y.A.; Welsh, A.W., 2011: Reproducibility of regional placental vascularity/perfusion measurement using 3D power Doppler. To assess reproducibility and regional variability of placental perfusion measurement using three-dimensional (3D) power Doppler VOCAL() (Virtual Organ Computer-aided AnaLysis). Twenty pregnant women at 26-34 weeks' gestation with normally gr...

King, B., 1983: Autumn feeding behaviour of a flock of black redstarts. Bristol Ornithology, 16: 40-41

Besznyak, I.; Pinter, E.; Armentano, L., 1964: The Antibiogram Of Thoracic Empyema And Its Local Antibiotic Therapy. Zeitschrift für Tuberkulose und Erkrankungen der Thoraxorgane 121: 83-87

Dalldorf, G.; Gifford, R., 1951: Clinical and epidemiologic observations of Coxsackie-virus infection. New England Journal of Medicine 244(23): 868-873

Carillon, R., 1980: Problems of the economic study of techniques for using biomass energy. Bulletin d'information du CNEEMA Centre national d'etudes et d'experimentation de machinisme agricole: (274) 1-4

Moretti Isabelle; Ngokwey Kombe, 1984: Ridge subduction and vertical motion of overriding plate. International Geological Congress, Abstracts = Congres Geologique International, Resumes 27(Vol

Eccles, T.R.; Shackleton, D.M., 1986: Correlates and consequences of social status in female bighorn sheep. Dominance-subordinance relationships among a captive group of adult female bighorn sheep (Ovis canadensis californiana ) were studied from May 1977 to December 1978. Social interactions between females were brief in duration and infrequent. Althou...