+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The prevalence of obstructive sleep apnea in symptomatic patients with syndromic craniosynostosis

, : The prevalence of obstructive sleep apnea in symptomatic patients with syndromic craniosynostosis. International Journal of Oral and Maxillofacial Surgery 45(2): 167-169

The reported prevalence of obstructive sleep apnea (OSA) in patients with syndromic craniosynostosis (SCS) varies due to inconsistent definitions of OSA, lack of uniform diagnostic testing, and different mixes of syndromic diagnoses. The purpose of this study was to determine the prevalence of OSA in symptomatic patients with SCS, and to determine whether this differs by phenotypic diagnosis. A retrospective cohort study of children with SCS was conducted. The primary outcome was presence of OSA diagnosed by polysomnography. The prevalence of OSA was calculated and stratified by diagnosis to compare differences in prevalence and severity (mild, moderate, or severe). The prevalence of OSA in symptomatic patients was 74.2%. Patients with Apert syndrome had the highest prevalence (80.6%), followed by Pfeiffer, Crouzon with acanthosis nigricans, and Crouzon syndromes (72.7%, 66.7%, and 64.7%, respectively). Severe OSA was most common in patients with Pfeiffer syndrome (45.5%), while patients with Apert and Crouzon syndromes were more likely to have moderate OSA (29.0% and 23.5%, respectively). Given that 56.4% of patients with SCS are symptomatic and that 74.2% of these symptomatic patients have OSA, it is recommended that a screening level I polysomnography be part of the clinical care for all patients with SCS.


PMID: 26602951

DOI: 10.1016/j.ijom.2015.10.003

Other references

Harcourt-Brown, F.Margaret., 2013: Diagnosis of renal disease in rabbits. There are differences in renal anatomy and physiology between rabbits and other domestic species. Neurogenic renal ischemia occurs readily. Reversible prerenal azotemia may be seen in conjunction with gut stasis. Potentially fatal acute renal fail...

Bischoff, F.R.; Krebber, H.; Kempf, T.; Hermes, I.; Ponstingl, H., 1995: Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. RanGAP1 is the GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Here, we report the amino acid sequence of RanGAP1, derived from cDNA and peptide sequences. We found it...

Roitman, I.; Felfili, J.M.; Rezende, A.V., 2008: Tree dynamics of a fire-protected cerrado sensu stricto surrounded by forest plantations, over a 13-year period (1991-2004) in Bahia, Brazil. Structural and floristic changes of a fire-protected cerrado sensu stricto are described over a 13-year period. The study site is located in a biological reserve (2,800 ha) surrounded by large Pinus spp. and Eucalyptus spp. plantations (36,000 ha...

Labar, P., 1973: Neurophysiology of sleep and treatment of nocturnal enuresis in children. Acta Psychiatrica Belgica 73(5): 608-619

Wang, J.; Jiao, S.; Wolff, J.A.; Knechtle, S.J., 1992: Gene transfer and expression in rat cardiac transplants. Transplantation 53(3): 703-705

Kimberley, T.J.; Schmidt, R.L.S.; Chen, M.; Dykstra, D.D.; Buetefisch, C.M., 2015: Mixed effectiveness of rTMS and retraining in the treatment of focal hand dystonia. Though the pathophysiology of dystonia remains uncertain, two primary factors implicated in the development of dystonic symptoms are excessive cortical excitability and impaired sensorimotor processing. The aim of this study was to determine the f...

Chase, C.C.Jr; Olson, T.A.; Hammond, A.C.; Menchaca, M.A., 1996: Effect of tropically adapted sire breed on preweaning calf performance. Journal of Animal Science 74(SUPPL 1): 13

Theodorou, M.K.; Smith, I.M., 1978: Reaction of bean leaves to injection with conidial suspensions of Colletotrichum lindemuthianum. When conidia were injected into intercellular spaces of expanding unifoliolate leaves of cultivars of Phaseolus vulgaris cultivars, susceptible leaf tissue collapsed within 3-4 days whilst resistant tissue showed no visible response.

Sinoto, D.; Sato, D., 1940: Colchicine polyploids in Fagopyrum. By placing one drop of colchicine solution on the plumule of germinating seeds each day for several days, a number of polyploid and mixoploid plants were obtained. Various meiotic irregularities were observed in both tetraploid and octoploid plant...

Cassidy, N.G., 1941: Some values of green manure crops. The values of green-manuring crops in connection with sugar cane are enumerated. Inoculation of the various leguminous crops with the proper N-fixing bacteria is recommended. Analyses of dry green-manure tissues are given for N, P2O5 and K2O.