geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The role of pancreatic polypeptide in the regulation of energy homeostasis


, : The role of pancreatic polypeptide in the regulation of energy homeostasis. Molecular and Cellular Endocrinology 418 Pt 1: 33-41

Imbalances in normal regulation of food intake can cause obesity and related disorders. Inadequate therapies for such disorders necessitate better understanding of mechanisms that regulate energy homeostasis. Pancreatic polypeptide (PP), a robust anorexigenic hormone, effectively modulates food intake and energy homeostasis, thus potentially aiding anti-obesity therapeutics. Intra-gastric and intra-intestinal infusion of nutrients stimulate PP secretion from the gastrointestinal tract, leading to vagal stimulation that mediates complex actions via the neuropeptide Y4 receptor in arcuate nucleus of the hypothalamus, subsequently activating key hypothalamic nuclei and dorsal vagal complex of the brainstem to influence energy homeostasis and body composition. Novel studies indicate affinity of PP for the relatively underexplored neuropeptide y6 receptor, mediating actions via the suprachiasmatic nucleus and pathways involving vasoactive intestinal polypeptide and insulin like growth factor 1. This review highlights detailed mechanisms by which PP mediates its actions on energy balance through various areas in the brain.

US$19.90

PMID: 26123585

DOI: 10.1016/j.mce.2015.06.028


Other references

Bindiganavile Sridhar, S.; Pluye, P.; Grad, R., 2014: In pursuit of a valid Information Assessment Method for continuing education: a mixed methods study. The Information Assessment Method (IAM) is a popular tool for continuing education and knowledge translation. After a search for information, the IAM allows the health professional to report what was the search objective, its cognitive impact, as...

Kurejová, M.; Lacinová, L'ubica., 2006: Effect of protein tyrosine kinase inhibitors on the current through the Ca(V)3.1 channel. In the present study, we have investigated the effects of protein tyrosine kinase (PTK) inhibitors on the Ca(V)3.1 calcium channel stably transfected in HEK293 cells using the whole-cell configuration of the patch-clamp technique. We have tested t...

Liu Kam biu; Fearn Miriam Lee, 1993: Where in the mud is Hurricane Camille?. Abstracts, Annual Meeting - Association of American Geographers 89: 140-141

Embley Robert; Hayes Dennis E., 1972: Site survey report for Site 142. Geophysical surveys and sediment properties off the northern coast of Brazil at 4 degrees N, 43 degrees W.

Sönmez, A.; Dinç, M.; Taşlıpınar, A.; Aydoğdu, A.; Meriç, C.; Başaran, Y.; Haymana, C.; Demir, O.; Yılmaz, İlker.; Azal, Ömer., 2017: Add on Exenatide Treatment is Beneficial in Poorly Controlled Obese Type 2 Diabetics under Intensive Insulin Regimens. <b>Background:</b> Intensive insulin treatment is bothersome in obese patients with type 2 diabetes mellitus. High insulin dosages further increase weight gain and the risk of hypoglycemia. Glucagon like peptide-1 receptor agonists dec...

Chatzivasileiadis, E.A.; Boon, J.J.; Sabelis, M.W., 2000: Accumulation and turnover of 2-tridecanone in Tetranychus urticae and its consequences for resistance of wild and cultivated tomatoes. In this study we assessed the dynamic changes of 2-tridecanone in a herbivorous mite (Tetranychus urticae) on tomato (Lycopersicon esculentum, cv. 'Moneymaker'), a plant with methyl ketones in the tetracellular tips of the glandular tric...

Campbell, Robert., 1998: Catch and effort analysis with uncertain stock and effort dynamics: southern bluefin tuna longline. Alaska Sea Grant Report, 98-01: 75-97

Hastings, Willard S., 1939: A suspended photo-micrographic camera. The camera and microscope are hung in a suspended frame vertically and the lamp axis is horizontal. An inflated invalid ring is used to absorb vibration.

T.L.Bucheyeki, C.Gwanama, M.Mgonja, M.Chisi, R.Folkertsma, 2008: Morphological characterization of Tanzanian sorghum [Sorghum bicolor (L) Moench] landraces. Eleven qualitative and 26 quantitative morphological traits were used to determine the genetic relationships in 37 sorghum landraces from Tanzania and two from Zambia. The objectives of this study were to: determine the genetic relationships and t...

Raabe, R.D.; Holtzmann, O.V., 1964: Studies on the control of Papaya anthracnose. This pa paw disease (Colletotrichum gloeosporioides) is severe in Hawaii, but use of Cu fungicides russets the fruits. Application of dithane M-45, manzate, captan, or phaltan at 2 lb./100 gal., with a spreader-sticker (except for captan), every 1...