+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Total Cavopulmonary Connection is Superior to Atriopulmonary Connection Fontan in Preventing Thrombus Formation: Computer Simulation of Flow-Related Blood Coagulation

, : Total Cavopulmonary Connection is Superior to Atriopulmonary Connection Fontan in Preventing Thrombus Formation: Computer Simulation of Flow-Related Blood Coagulation. Pediatric Cardiology 36(7): 1436-1441

The classical Fontan route, namely the atriopulmonary connection (APC), continues to be associated with a risk of thrombus formation in the atrium. A conversion to a total cavopulmonary connection (TCPC) from the APC can ameliorate hemodynamics for the failed Fontan; however, the impact of these surgical operations on thrombus formation remains elusive. This study elucidates the underlying mechanism of thrombus formation in the Fontan route by using a two-dimensional computer hemodynamic simulation based on a simple blood coagulation rule. Hemodynamics in the Fontan route was simulated with Navier-Stokes equations. The blood coagulation and the hemodynamics were combined using a particle method. Three models were created: APC with a square atrium, APC with a round atrium, and TCPC. To examine the effects of the venous blood flow velocity, the velocity at rest and during exercise (0.5 and 1.0 W/kg) was measured. The total area of the thrombi increased over time. The APC square model showed the highest incidence for thrombus formation, followed by the APC round, whereas no thrombus was formed in the TCPC model. Slower blood flow at rest was associated with a higher incidence of thrombus formation. The TCPC was superior to the classical APC in terms of preventing thrombus formation, due to significant blood flow stagnation in the atrium of the APC. Thus, local hemodynamic behavior associated with the complex channel geometry plays a major role in thrombus formation in the Fontan route.


PMID: 26024646

DOI: 10.1007/s00246-015-1180-y

Other references

Fujiwara, A.; Nishida Umehara, C.; Sakamoto, T.; Okamoto, N.; Nakayama, I.; Abe, S., 2001: Improved fish lymphocyte culture for chromosome preparation. Cytogenetic methodology is still underdeveloped in fishes compared with mammals. Culture condition for fish lymphocytes was optimized to improve chromosome preparation using the rainbow trout, (Oncorhynchus mykiss), as a model after changing the c...

Prezant R.S., 1987: Functional morphology and ecology of the antarctic bivalve lissarca notocadensis. American Zoologist 27(4): 82A

Janczyk, FS.W., 1956: Anatomie von Siro duricorius Joseph im Vergleich mit anderen Opilioniden. Sitzungsberichte der Oesterreichischen Akademie der Wissenschaften Abt I: 165: 475-522

Adcock, H., 2008: Mental health services in England fail to meet children's needs, commissioner says. Bmj 337: A1944-A1944

Ma, D.Z., 1981: Cure of two cases of preexcitation syndrome with local intramyocardial injection of dehydrated alcohol. Zhonghua Nei Ke Za Zhi 20(11): 659-661

Bachik M.; Haft J.I., 1981: Incidence of graft closure and progression of coronary disease in symptomatic patients post coronary bypass operation. Clinical Research 29(3): 643A

Sakamoto, T.; Schmitz, S.; Molloy, J.E.; Veigel, C.; Wang, F.; Sellers, J.R., 2002: Effect of myosin V neck length on processivity and working stroke. Molecular Biology of the Cell 13(Supplement): 457a, Nov

Zacà, V.; Rastogi, S.; Imai, M.; Wang, M.; Sharov, V.G.; Jiang, A.; Goldstein, S.; Sabbah, H.N., 2007: Chronic monotherapy with rosuvastatin prevents progressive left ventricular dysfunction and remodeling in dogs with heart failure. Objectives This study examined the effects of long-term monotherapy with rosuvastatin (RSV) on the progression of left ventricular (LV) dysfunction and remodeling in dogs with heart failure (HF).Background 3-hydroxy-3-methylglutaryl coenzyme A re...

Woodring, W.P., 1925: Arca Patricia Sowerby, A Miocene Fossil From The Dominican Republic. Science 62(1614): 518-519

Crawford, G.A.; Stuart, A.K., 1982: Industrial applications of electrolytic hydrogen (EH2). While the potential applications of EH2 on an industrial scale cover a wide variety including chemicals, metallurgy, petroleum upgrading, synfuel production, heating and transportation, it is likely that the earliest applications will be those for...