+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Treatment modalities for advanced ALK-rearranged non-small-cell lung cancer

, : Treatment modalities for advanced ALK-rearranged non-small-cell lung cancer. Future Oncology 12(7): 945-961

The ALK gene plays a key role in the pathogenesis of non-small-cell lung cancer (NSCLC). Patients with NSCLC harboring an ALK-rearrangement represent the second oncogene addiction to be identified in this disease. Crizotinib was the first ALK inhibitor showing pronounced clinical activity, and is now a reference treatment for ALK-positive NSCLC disease. However, despite initial impressive responses to crizotinib, acquired resistance almost invariably develops within 12 months. The pressing need for effective second-line agents has prompted the rapid development of next-generation ALK inhibitors. These agents, notably ceritinib and alectinib as the most developed, have a higher potency against ALK than crizotinib, along with activity against tumors harboring crizotinib-resistant mutations and potentially improved CNS penetration.


PMID: 26892300

DOI: 10.2217/fon.16.15

Other references

Dupré, N.; Cossette, L.; Hand, C.K.; Bouchard, J.P.; Rouleau, G.A.; Puymirat, J., 2001: A founder mutation in French-Canadian families with X-linked hereditary neuropathy. Background: The aim of the present study was to identify the mutations in the connexin 32 gene in French-Canadian families with X-linked Charcot-Marie-Tooth disease (CMTX). Methods: Molecular analysis was performed by nonisotopic single strand con...

Plambeck, C.J.; Graves, D.A.; Reuter, R.A.; Berg, S.P., 1994: Use of monoclonal antibodies to study the topography of photosystem II peptides. Plant Physiology (Rockville) 105(1 SUPPL ): 79

Swart, G.W.M., 2003: International Melanoma Research Congress--Foundation for Melanoma Research. 21-24 June 2003, Philadelphia, PA, USA. Idrugs 6(8): 752-754

Rajput, R.L.; Shrivastava, U.K., 1999: Influence of varieties, sowing date and seed rate on physiological parameters and seed yield of soybean (Glycine max). In a field experiment in 1995-96 in Madhya Pradesh, 3 soyabean cultivars were sown on 11, 21 or 31 July at the rate of 80, 100 or 120 kg seed/ha. Delaying sowing decreased seed yield. Seed yield was highest with 120 kg seed/ha. Cv. JS 71-05 and JS...

Cooper J.A.; Mortimer G.E.; James P.R., 1988: Rate of Arunta Inlier evolution at the eastern margin of the Entia Dome, central Australia. Zircon dating in the Entia Dome of the Arunta Inlier helps to temporally define the multiphase, successive Strangways and Harts Range Orogenies. It appears that the entire activity of both orogenies took place between 1767 ± 2 Ma and 1731 ± 1 Ma...

Souto, C.B., 1959: The problem of dehydration in infancy. Pediatria Pratica 30: 187-192

Chamoun, G.C.; Schilder, F.; Brøns, M., 2011: Stabilization of vortices in the wake of a circular cylinder using harmonic forcing. We explore whether vortex flows in the wake of a fixed circular cylinder can be stabilized using harmonic forcing. We use Föppl's point vortex model augmented with a harmonic point source-sink mechanism which preserves conservation of mass a...

Oliver, D.S.; DiNardo, L.J.; Monahan, M.; Kay, S.; Kuta, A.J., 1995: Pathologic quiz case 2. Odontogenic fibromyxoma. Archives of Otolaryngology--Head & Neck Surgery 121(7): 805, 807-805, 807

Lee, G.C.; Long, S.Wesley.; Musser, J.M.; Beres, S.B.; Olsen, R.J.; Dallas, S.D.; Nunez, Y.O.; Frei, C.R., 2015: Comparative whole genome sequencing of community-associated methicillin-resistant Staphylococcus aureus sequence type 8 from primary care clinics in a Texas community. Our understanding of the molecular dynamics driving the community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) epidemic at the whole genome level is limited. We sought to assess the use of whole genome sequencing (WGS) to evalu...

Watanabe T.; Okada S.; Shiomi T., 1975: Long term cultivation of mouse peripheral blood mononuclear cells in vitro. Mie Medical Journal 24(2-3): 195-202, 1974