geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Tumor budding is an independent risk factor for lymph node metastasis in cutaneous squamous cell carcinoma: a single center retrospective study


, : Tumor budding is an independent risk factor for lymph node metastasis in cutaneous squamous cell carcinoma: a single center retrospective study. Journal of Cutaneous Pathology 43(9): 766-771

Although tumor budding is acknowledged as a risk factor for lymph node metastasis in certain types of carcinoma, it is not well investigated in cutaneous squamous cell carcinomas (SCCs). In this study, we analyzed the correlation between tumor budding and nodal metastasis in cutaneous SCC. Histopathologic specimens of 15 metastasizing and 144 non-metastasizing cutaneous SCC were retrospectively reviewed. Cut-off point for tumor budding was determined at five or more foci of an isolated cancer cell or a cluster comprising <5 cells /1.23 mm(2) in the invasive front of the tumor under hematoxylin and eosin sections. Tumor budding was positive in 93.3% of metastasizing cutaneous SCC and 25.7% of non-metastasizing cutaneous SCC, respectively (p < 0.0001). In multivariate analysis, tumor budding was an independent risk factor for nodal metastasis among the other risk factors (tumor size, tumor thickness, Clark level and poor differentiation) (p = 0.0021). In combination with tumor thickness >4 mm, tumor budding became a better marker for predicting nodal metastasis (sensitivity 93.3%, specificity 84.7%). In our cohort, tumor budding was an independent risk factor for nodal metastasis. Our data suggests the promising role of tumor budding in risk evaluation of cutaneous SCC.

US$19.90

PMID: 27226362

DOI: 10.1111/cup.12740


Other references

Yanushauskaite, V.B.; Kozlov, L.V.; Antonov, V.K., 1974: Milk-clotting and proteinase activity of anionite-absorbed modified alpha -chymotrypsin. Effects of absorption of alpha -chymotrypsin by the ion-exchange materials Amberlite CG-400, DEAE-cellulose DE-32 and DEAE-Sephadex A-50 on its proteolytic activity towards N-acetyl-L-tyrosine ethyl ester and casein and its capacity to coagulate m...

Roshchina, L.F., 1958: Effect of various quantities of sodium chloride in food on higher nervous function & on blood pressure of dogs with experimental hypertension. Voprosy Pitaniia 17(5): 14-19

Zavitzianos, G., 1972: Fetishism and exhibitionism in women and their relations with psychopathy and kleptomania. Revue Francaise de Psychanalyse 36(3): 475-489

Ronchese, F.; Kern, A.B., 1971: Longitudinal pigmentation of the nails. JAMA 216(8): 1352-1352

Huang, H.M.; Gibson, G.E., 1989: Phosphatidylinositol metabolism during in vitro hypoxia. The effects of in vitro histotoxic hypoxia (0.5 mM KCN) on potassium-stimulated phosphatidylinositol turnover were determined. In rat cortical slices that were prelabeled with [2-3H]inositol, depolarization with 60 mM KCl increased [2-3H]inositol...

Macgregor, J.E.; Fraser, M.E.; Mann, E.M., 1965: Screening For Cancer Of The Cervix. Lancet 1(7391): 910-910

Pulte, D.; Gondos, A.; Brenner, H., 2010: Expected long-term survival of patients diagnosed with acute myeloblastic leukemia during 2006-2010. Treatment of acute myeloblastic leukemia (AML) has evolved over the past several decades. Therefore, currently available estimates of long-term survival, which are based on survival for patients treated with potentially now obsolete protocols, may...

Shimanaka, T., 1968: Clinical experiences with Biosmin for constipation during pregnancy and the puerperium. Sanfujinka No Jissai. Practice of Gynecology and Obstetrics 17(5): 465-468

Fily, J.; Colin, J.; Renard, G., 1983: Methods of eyelid reconstruction. Bulletin des Societes D'ophtalmologie de France 83(6-7): 887-889

Pien, J., 1974: Recycling. 28. study of the fatty phase of milk. 5. study of churning. Technique laitiere: 29 (803) 15