+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity

, : Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes & Metabolic Syndrome 9(4): 299-304

There is growing consensus in the literature that inflammation plays a central role in the pathophysiology of obesity and type 2 diabetes mellitus (T2DM) and cardiovascular complications. Neutrophil-to-lymphocyte ratio (NLR) provides a simple method for assessment of inflammatory status and it is a new, inexpensive marker. The aim of the present study was to investigate the predictive value of preprocedural (before the OGTT) NLR on development of type 2 diabetes (T2DM) in morbid obesity patients (MOP). 306 MOP (body mass index ≥ 40 kg/m(2)) and 95 normal weight patients with normal OGTT [fasting plasma glucose (FPG)<100mg/dL. Two-hour glucose during OGTT<140 mg/dL] were evaluated in this study. The mean ± SD NLR of MOP was significantly higher than that of patients with normal weight healthy patients (3.67 ± 0.95 vs. 1.82 ± 1.02, P<0.001, respectively). In receiver operating characteristics curve analysis, NLR>3.12 had 79.2% sensitivity and 64.9% specificity in predicting T2DM. Logistic regression analysis showed that elevated NLR (OR: 2.577, 95% CI: 1.363-4.872, P=0.004) was an independent variable for predicting T2DM in MOP. MOP have higher NLR than healthy controls. High NLR is a powerful and independent predictor of T2DM in MOP. Elevated NLR levels are usually considered as an inflammatory marker. The results of this study suggested that inflammation plays a role in the pathogenesis of T2DM with MOP.


PMID: 25470646

DOI: 10.1016/j.dsx.2014.04.009

Other references

Costers, S.; Vanhee, M.; Van Breedam, W.; Van Doorsselaere, J.; Geldhof, M.; Nauwynck, H.J., 2011: GP4-specific neutralizing antibodies might be a driving force in PRRSV evolution. The structural envelope glycoprotein GP4 of European porcine reproductive and respiratory syndrome virus (PRRSV) strains contains a highly variable neutralizing epitope that is susceptible to neutralizing antibody-mediated selective pressure in vi...

Gould, M.S.; Genetelli, E.J., 1978: Heavy metal complexation behavior in anaerobically digested sludges. Heavy metal interactions with anaerobically digested sludges were examined by equilibrating sludge solids with solutions containing acetate salts of Zn, Ni, Cu and Cd over the range of pH 5.0-8.0. The partitioning of the metals with the solids sug...

GIACOMELLI.R.; da Vinci, L., 1952: Leonardo and human flight. Rivista di Medicina Aeronautica 15(4): 561-84; Concl

Proppe, A.; Schreus, H.T., 1970: In memoriam Hans Theo Schreus. Cosmetologica 19(4): 105-108

Noble, A., 1934: Redstarts and Pied Flycatchers. Vasculum Newcastle-on-Tyne, 20: 81-84

Judet, R.; Judet, J.; Lord, G., 1959: Results of treatment of stiffness of the knee caused by arthrolysis and disinsertion of the quadriceps femoris. Memoires. Academie de Chirurgie 85: 645-654

Salikhova, R.A.; Umnova, N.V.; Fomina, M.M.; Poroshenko, G.G., 1994: A study of antimutagenic effect of bioginseng. We studied antimutagenic properties of bioginseng, a biotechnological product obtained from the callus culture of the ginseng root cells by alcohol extraction (bioginseng-1) and lyophilization (bioginseng-2). We have estimated the frequency of sis...

Rotmensch, S.; Luo, J.S.; Liberati, M.; Belanger, K.; Mahoney, M.J.; Hobbins, J.C., 1992: Fetal humeral length to detect Down syndrome. Our aim was to evaluate the utility of ultrasonographic humeral length measurements for detection of fetuses with Down syndrome in the midtrimester of gestation. Ultrasonographic biometry data obtained before genetic amniocenteses on 43 fetuses wi...

Hadjipavlou-Litina, D.; Magoulas, G.E.; Bariamis, S.E.; Tsimali, Z.; Avgoustakis, K.; Kontogiorgis, C.A.; Athanassopoulos, C.M.; Papaioannou, D., 2014: Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. A series of conjugates (MNX-CO-PA) of minoxidil (MNX) with the polyamines (PAs) putrescine (PUT), spermidine (SPD) and spermine (SPM) as well as dopamine were produced through activation of MNX with N,N'-carbonyldiimidazole, followed by react...

Podio, G., 1941: The action of a diet very rich in fats on estrus, fecundity, pregnancy, fetus development in rabbit. The author experimentally demonstrates the harmful action of an excessive supply of substances with a high content of unsaturated fatty acid radicals, on the rabbit's estrus, fecundity, vitality and number of fetuses.