geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Vaccination Against Tuberculosis With Whole-Cell Mycobacterial Vaccines


, : Vaccination Against Tuberculosis With Whole-Cell Mycobacterial Vaccines. Journal of Infectious Diseases 214(5): 659-664

Live attenuated and killed whole-cell vaccines (WCVs) offer promising vaccination strategies against tuberculosis. A number of WCV candidates, based on recombinant bacillus Calmette-Guerin (BCG), attenuated Mycobacterium tuberculosis, or related mycobacterial species are in various stages of preclinical or clinical development. In this review, we discuss the vaccine candidates and key factors shaping the development pathway for live and killed WCVs and provide an update on progress.

US$19.90

PMID: 27247343

DOI: 10.1093/infdis/jiw228


Other references

Huddlestone, J.R.; Oldstone, M.B., 1979: T suppressor (TG) lymphocytes fluctuate in parallel with changes in the clinical course of patients with multiple sclerosis. Aberrant immune responses to several unrelated antigens observed in patients with multiple sclerosis have suggested faulty regulation of immunocompetent cells. Recently human T lymphocytes have been segregated into subpopulations. T lymphocytes th...

Rieder, U.; Lang, K.; Kreutz, C.; Polacek, N.; Micura, R., 2009: Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers. All in a knot. The smallest riboswitch forms a pseudoknot in solution. This is demonstrated for preQ(1) class I aptamers by mutational analysis in combination with (1)H NMR-based structure probing. How pseudoknot formation mediates the mRNA respon...

Domenico, Pace, 1930: Atrio-ventricular nodules in the right heart of the turkey. In the heart of the adult turkey, the semilunar valve is continuous with the anterior wall of the right ventricle; in the right heart there are also special formations, described by the author in 1910, as atrio-ventricular nodules. These nodules a...

Gal, J.; Csecsei, G., 2007: Hypoplasy of tail muscle fibres in a Madagascarian day gecko (Phelsuma madagascariensis kochi). Case report. Hypoplasy of the tail musculature was detected in a Madagascarian day gecko (Phelsuma madagascariensis kochi) while studying the background of abnormal tail posture, which was a well-known phenomenon to lizard keepers [Hungary, date not given]. At...

Cicirata, F.; Zappalà, A.; Serapide, M.Francesca.; Parenti, R.; Pantò, M.Rosita.; Paz, C., 2005: Different pontine projections to the two sides of the cerebellum. This study analyzed the projections of the basilar pontine nuclei (BPN) and of the nucleus reticularis tegmenti pontis (NRTP) to the two sides of the cerebellum in the rat. It showed that the two sides of the cerebellar cortex were innervated by d...

Cravens, S.L.; Stivers, J.T., 2016: Comparative Effects of Ions, Molecular Crowding, and Bulk DNA on the Damage Search Mechanisms of hOGG1 and hUNG. The energetic nature of the interactions of DNA base excision repair glycosylases with undamaged and damaged DNA and the nuclear environment are expected to significantly impact the time it takes for these enzymes to search for damaged DNA bases....

Hironaka, K.; Makino, H.; Yamasaki, Y.; Ota, Z., 1993: Renal basement membranes by ultrahigh resolution scanning electron microscopy. Three-dimensional ultrastructures of basement membranes of the rat kidney were investigated with an ultrahigh resolution scanning electron microscope (HSEM) equipped with a resolving power of 0.5 nm. All cellular components were extracted from ren...

Matsuo, K.; Isogai, E.; Araki, Y., 2001: Control of immunologically crossreactive leptospiral infection by administration of lipopolysaccharides from a nonpathogenic strain of Leptospira biflexa. In our previous paper (Matsuo, K., Isogai, E., and Araki, Y., Carbohydr. Res., 328: 517-524, 2000), antigenic polysaccharides obtained from the lipopolysaccharide (LPS) fraction of a nonpathogenic leptospira, Leptospira biflexa patoc Patoc I, are...

Weinthrop, G., 1982: Nursing care study: she never asked for anything. Nursing Mirror 155(13): 65-66

Sato, S., 1970: State medicine and interpretation of related laws. (3). Key points of the state medicine. Japanese Journal of Nurses' Education 11(8): 56-60