geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

m-Trifluoromethyl-diphenyldiselenide as a pharmacological tool to treat preference symptoms related to AMPH-induced dependence in rats


, : m-Trifluoromethyl-diphenyldiselenide as a pharmacological tool to treat preference symptoms related to AMPH-induced dependence in rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry 66: 1-7

Amphetamine (AMPH) abuse is a world concern and a serious public health problem. Repeated administration of high doses of AMPH induces neuropsychiatric consequences, including addiction, reward and psychosis, whose pharmacological treatment has shown limited effectiveness. The m-trifluoromethyl-diphenyldiselenide [(m-CF3-PhSe)2] has been documented as a promising pharmacological agent in different animal models related to oxidative damage. In this study, we examined the influence of (m-CF3-PhSe)2 on withdrawal following re-exposure to AMPH. Wistar rats received d,l-AMPH or saline in the conditioned place preference (CPP) paradigm for 8days. Then, half of each initial (AMPH or saline) experimental group was treated with (m-CF3-PhSe)2 or vehicle, resulting in four final groups: i) Saline/vehicle; ii) (m-CF3-PhSe)2/saline; iii) AMPH/vehicle; and iv) AMPH/(m-CF3-PhSe)2. After fourteen days of (m-CF3-PhSe)2 treatment, animals were re-exposed to AMPH or vehicle in the CPP paradigm for three more days in order to assess drug re-conditioning and memory/locomotor activity, performed 24h after AMPH re-exposure in the CPP and the Y maze, respectively. Subsequently, ex-vivo assays were carried out in samples of the prefrontal cortex (PFC) of the animals. The (m-CF3-PhSe)2 treatment was able to prevent AMPH-induced re-conditioning symptoms in rats. Behavioral observations in the Y maze task showed no significant changes. AMPH exposure was able to increase 5-HT uptake as well as oxidative damage in the PFC, whereas (m-CF3-PhSe)2 treatment exerted a preventative effect against these alterations. The current findings suggest that (m-CF3-PhSe)2 might be considered a promising therapeutic tool for AMPH-induced addiction.

US$19.90

PMID: 26555614

DOI: 10.1016/j.pnpbp.2015.11.002


Other references

Stark, T.M.; Armstrong, R.W., 1999: Carfentanil-related analgesics via resin capture of UGI products. Abstracts of Papers American Chemical Society 217(1-2): ORGN 174

Zhang, H.; Sun, H.; Takeda, Y., 1995: Four new taxanes from the roots of Taxus yunnanensis. Four new taxoids (1-4) were isolated from the roots of Taxus yunnanensis. Three of the new compounds were analogues of taxuyunnanine C and the fourth was a 2-deacetoxytaxuyunnanine C derivative. The structures were elucidated by spectroscopic meth...

Shankar R.; Raghavan B.R., 1996: Geoscience component of school curriculum in Indian schools. AGID Special Publication Series 19: 71-78

Spolverato, G.; Montgomery, E.; Kamel, I.; Pawlik, T.M., 2015: Endometrial stromal sarcoma presenting as large bleeding left upper quadrant mass. Endometrial stromal sarcoma (ESS) represents only 0.2% of all uterine malignancies. Even fewer cases have been reported on patients presenting with symptomatic disease. We report the case of young lady presenting with a large bleeding abdominal ma...

D.L.on-Rodriguez, L.; Lubag, A.Josue.M.; Sherry, A.Dean., 2012: Imaging free zinc levels in vivo - what can be learned?. Our ever-expanding knowledge about the role of zinc in biology includes its role in redox modulation, immune response, neurotransmission, reproduction, diabetes, cancer, and Alzheimers disease is galvanizing interest in detecting and monitoring th...

Haspelova-Horvatovicova, A., 1963: Contribution to the physiology of chlorophyll-deficient lethal plants of Z. mays. IV. Changes in the pigment components of the leaf under the influence of artificial nutrition. The pigments but not their proportions were the same in (1) normal green seedlings, (2) albinotic seedlings and (3) albinotic seedlings receiving supplementary sucrose. The ratio of chlorophyll a: b reached 3: 1 in (1) and 1.8: 1 in (3); in (2) it...

Kotecha, D.; Manzano, L.; Krum, H.; Rosano, G.; Holmes, J.; Altman, D.G.; Collins, P.D.; Packer, M.; Wikstrand, J.; Coats, A.J.S.; Cleland, J.G.F.; Kirchhof, P.; von Lueder, T.G.; Rigby, A.S.; Andersson, B.; Lip, G.Y.H.; van Veldhuisen, D.J.; Shibata, M.C.; Wedel, H.; Böhm, M.; Flather, M.D., 2016: Effect of age and sex on efficacy and tolerability of β blockers in patients with heart failure with reduced ejection fraction: individual patient data meta-analysis. To determine the efficacy and tolerability of β blockers in a broad age range of women and men with heart failure with reduced ejection fraction (HFrEF) by pooling individual patient data from placebo controlled randomised trials. Prospectively d...

Behringer A.; Wirbatz A., 1987: Chronic borrelia infection of the central nervous system. A few years ago meningoradiculitis Garin-Bujadoux-Bannwarth (Bannwarth's syndrome) was discovered to be a neurological manifestation of Lyme disease transmitted by tick-bites and caused by Ixodes-ricinus-spirochaete (Borrelia-burgdorferi). No...

Anonymous, 2013: Sailing the seas for sight. Nursing Times 108(43): 31-31

Dragojevic, B.; Ercegovac, N., 1952: Diagnosis and therapy of the cervical rib. Srpski Arhiv Za Celokupno Lekarstvo 80(11): 1060-1064